Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | NPC1 | O15118 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.49 |
| ▸ | HK1 | P19367 | 1/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
| ▸ | GALK1 | P51570 | 1/20 | 0.49 |
| ▸ | BLM | P54132 | 1/20 | 0.49 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.49 |
| ▸ | BRD4 | O60885 | 1/20 | 0.44 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.44 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17506418 | 0.82 | AHR (0.50) | MAPTNPC1KDM4EMAPK1MEN1 | |
| SCHEMBL3764990 | 0.79 | DPP4 (0.41) | DPP9DPP7HSP90B1TRAP1 | |
| SCHEMBL2557972 | 0.79 | AHR (0.46) | MEN1KMT2ABRD4LMNAAHR | |
| SCHEMBL3769645 | 0.79 | MAPK1 (0.63) | MAPTNPC1KDM4EMAPK1MEN1 | |
| SCHEMBL2533362 | 0.76 | NOTUM (0.64) | MAPTNPC1MEN1HSP90AA1KMT2A | |
| SCHEMBL29758685 | 0.76 | NOTUM (0.64) | MAPTNPC1MEN1HSP90AA1KMT2A | |
| SCHEMBL27993916 | 0.75 | MAPK1 (0.48) | MAPTNPC1KDM4EMAPK1MEN1 | |
| SCHEMBL2818152 | 0.72 | MAPK1 (0.63) | MAPTNPC1MAPK1MEN1KMT2A | |
| SCHEMBL2824864 | 0.71 | BRD4 (0.56) | MAPTNPC1MEN1KMT2ABRD4 | |
| SCHEMBL30231301 | 0.68 | CALCRL (0.58) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2250157-A1 | NOVEL HETEROCYCLIC COMPOUNDS | Panacea Biotec Limited (IN) | 2010-11-17 | — | — | EP | disclosed |
| WO-2009093269-A1 | NOVEL HETEROCYCLIC COMPOUNDS | PANACEA BIOTEC LIMITED (IN) | 2009-07-30 | — | — | WO | disclosed |