Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A2 | P43354 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.36 |
| ▸ | ALDH1A3 | P47895 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | PKM | P14618 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL218442 | 0.72 | NR4A2 (0.47) | NR4A2KCNH2CYP11B1CYP11B2ALDH1A3 | |
| SCHEMBL218150 | 0.71 | NR4A2 (0.46) | NR4A2KCNH2CYP11B1CYP11B2ALDH1A3 | |
| SCHEMBL216882 | 0.67 | NR4A2 (0.45) | NR4A2KCNH2CYP11B1CYP11B2ALDH1A3 | |
| SCHEMBL3429756 | 0.63 | NR4A2 (0.69) | NR4A2KCNH2CYP11B1CYP11B2ALDH1A3 | |
| SCHEMBL20449105 | 0.59 | RAB9A (0.41) | KCNH2CYP11B1CYP11B2NPC1RAB9A | |
| SCHEMBL3433614 | 0.59 | NR4A2 (0.65) | NR4A2KCNH2CYP11B1CYP11B2ALDH1A3 | |
| SCHEMBL3432610 | 0.58 | NR4A2 (0.67) | NR4A2KCNH2CYP11B1CYP11B2ALDH1A3 | |
| SCHEMBL1472110 | 0.58 | NR4A2 (1.00) | NR4A2KCNH2CYP11B1CYP11B2ALDH1A3 | |
| SCHEMBL3431737 | 0.58 | NR4A2 (0.75) | NR4A2KCNH2CYP11B1CYP11B2ALDH1A3 | |
| SCHEMBL3430915 | 0.57 | NR4A2 (0.68) | NR4A2KCNH2CYP11B1CYP11B2ALDH1A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2262804-A1 | POLYSUBSTITUTED DERIVATIVES OF 6-HETEROARYL-IMIDAZO[L,2- A] PYRIDINES, AND PREPARATION AND THERAPEUTIC USE THEREOF | Sanofi-aventis (FR) | 2010-12-22 | — | — | EP | disclosed |
| WO-2009144392-A1 | POLYSUBSTITUTED DERIVATIVES OF 6-HETEROARYL-IMIDAZO[L,2- Α] PYRIDINES, AND PREPARATION AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2009-12-03 | — | — | WO | disclosed |