⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5493927 | 0.97 | MAPT (0.30) | — | |
| SCHEMBL12545193 | 0.97 | MAPT (0.30) | — | |
| SCHEMBL12712328 | 0.97 | MAPT (0.30) | — | |
| SCHEMBL24052332 | 0.87 | CHRNA7 (0.34) | — | |
| SCHEMBL20976956 | 0.84 | MAPT (0.37) | — | |
| SCHEMBL22504846 | 0.84 | — | — | |
| SCHEMBL23939736 | 0.82 | — | — | |
| SCHEMBL24454854 | 0.81 | — | — | |
| SCHEMBL407168 | 0.81 | SMN1; SMN2 (0.31) | — | |
| SCHEMBL1102338 | 0.81 | SMN1; SMN2 (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230265116-A1 | DEGRADATION OF (EGFR) BY CONJUGATION OF EGFR INHIBITORS WITH E3 LIGASE LIGAND AND METHODS OF USE | BEONE MEDICINES I GMBH (CH) | 2023-08-24 | — | — | US | disclosed |
| US-20230248834-A1 | DEGRADATION OF (EGFR) BY CONJUGATION OF EGFR INHIBITORS WITH E3 LIGASE LIGAND AND METHODS OF USE | BEONE MEDICINES I GMBH (CH) | 2023-08-10 | — | — | US | disclosed |
| WO-2020210320-A1 | SUBSTITUTED L,2-DIHYDRO-3H-PYRAZOLO[3,4-D]PYRIMIDIN-3-ONES | RECURIUM IP HOLDINGS, LLC (US) | 2020-10-15 | — | — | WO | disclosed |
| WO-2019173082-A1 | SUBSTITUTED L,2-DIHYDRO-3H-PYRAZOLO[3,4-D]PYRIMIDIN-3-ONES | Zeno Royalties & Milestones, LLC (US) | 2019-09-12 | — | — | WO | disclosed |
| WO-2019070727-A2 | NONVIRAL GENE TRANSFER TO THE SUPRACHOROIDAL SPACE | THE JOHNS HOPKINS UNIVERSITY (US) | 2019-04-11 | — | — | WO | disclosed |
| US-8772463-B2 | Fluorescent dye-labeled glucose bioprobe, synthesis method and usage thereof | SNU R&DB FOUNDATION (KR) | 2014-07-08 | — | — | US | disclosed |
| US-20110059477-A1 | FLUORESCENT DYE-LABELED GLUCOSE BIOPROBE, SYNTHESIS METHOD AND USAGE THEREOF | SNU R&DB FOUNDATION (KR) | 2011-03-10 | — | — | US | disclosed |