Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.44 |
| ▸ | MAPT | P10636 | 5/20 | 0.44 |
| ▸ | GAA | P10253 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | CASP1 | P29466 | 1/20 | 0.44 |
| ▸ | CASP7 | P55210 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | CA7 | P43166 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 3/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10355104 | 0.86 | CA1 (0.52) | KDM4EMAPTGAAALDH1A1GLA | |
| SCHEMBL15970899 | 0.81 | KDM4E (0.46) | KDM4EMAPTGAAALDH1A1GLA | |
| SCHEMBL29473216 | 0.81 | KDM4E (0.51) | KDM4EMAPTGAAALDH1A1GLA | |
| SCHEMBL2720327 | 0.81 | KDM4E (0.51) | KDM4EMAPTGAAALDH1A1GLA | |
| SCHEMBL26046781 | 0.80 | KDM4E (0.46) | KDM4EMAPTGAAALDH1A1GLA | |
| SCHEMBL18031415 | 0.79 | KDM4E (0.58) | KDM4EMAPTGAAALDH1A1GLA | |
| SCHEMBL18301336 | 0.79 | CA12 (0.46) | KDM4EMAPTGAAALDH1A1GLA | |
| SCHEMBL3709901 | 0.78 | CA1 (0.44) | KDM4EMAPTGAAALDH1A1GLA | |
| SCHEMBL3717095 | 0.78 | CA1 (0.44) | KDM4EMAPTGAAALDH1A1GLA | |
| SCHEMBL3652117 | 0.78 | KDM4E (0.47) | KDM4EMAPTGAAALDH1A1GLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010146351-A1 | INDOLYLMETHYL-MORPHOLINE DERIVATIVES AS KINASE INHIBITORS | UCB PHARMA S.A. (BE) | 2010-12-23 | — | — | WO | disclosed |