Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 4/20 | 0.52 |
| ▸ | CA2 | P00918 | 4/20 | 0.52 |
| ▸ | CA12 | O43570 | 3/20 | 0.52 |
| ▸ | CA7 | P43166 | 3/20 | 0.52 |
| ▸ | CA9 | Q16790 | 3/20 | 0.52 |
| ▸ | CA14 | Q9ULX7 | 3/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.50 |
| ▸ | GAA | P10253 | 3/20 | 0.50 |
| ▸ | POLB | P06746 | 3/20 | 0.50 |
| ▸ | XDH | P47989 | 2/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.50 |
| ▸ | GFER | P55789 | 1/20 | 0.50 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.50 |
| ▸ | RELA | Q04206 | 1/20 | 0.50 |
| ▸ | FUT7 | Q11130 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2720327 | 0.90 | KDM4E (0.51) | CA1CA2CA12CA7CA9 | |
| SCHEMBL29473216 | 0.90 | KDM4E (0.51) | CA1CA2CA12CA7CA9 | |
| SCHEMBL18031415 | 0.89 | KDM4E (0.58) | CA1CA2CA12CA7CA9 | |
| SCHEMBL18301336 | 0.89 | CA12 (0.46) | CA1CA2CA12CA7CA9 | |
| SCHEMBL3709901 | 0.87 | CA1 (0.44) | CA1CA2CA12CA7CA9 | |
| SCHEMBL3717095 | 0.87 | CA1 (0.44) | CA1CA2CA12CA7CA9 | |
| SCHEMBL3652117 | 0.87 | KDM4E (0.47) | CA1CA2CA12CA7CA9 | |
| SCHEMBL15970899 | 0.87 | KDM4E (0.46) | CA1CA2CA12CA7CA9 | |
| SCHEMBL3431753 | 0.86 | KDM4E (0.44) | CA1CA2CA12CA7CA9 | |
| SCHEMBL15970661 | 0.83 | XDH (0.45) | CA1CA2CA12CA7CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0230532-B1 | 2-[(3,5-Dihalo-4-Aminobenzyl)] Imidazolines | ABBOTT LABORATORIES (US) | 1990-09-26 | — | — | EP | disclosed |
| EP-0230532-A1 | 2-[(3,5-Dihalo-4-Aminobenzyl)] Imidazolines | ABBOTT LABORATORIES (US) | 1987-08-05 | — | — | EP | disclosed |
| US-4665095-A | Use of 2-[(3,5-dihalo-4-aminobenzyl)]imidazolines to stimulate alpha-1 adrenergic receptors and to treat nasal congestion | ABBOTT LABORATORIES (US) | 1987-05-12 | — | — | US | disclosed |