Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | CA1 | P00915 | 5/20 | 0.43 |
| ▸ | CA2 | P00918 | 5/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 5/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25397961 | 0.85 | PSMB5 (0.42) | POLBCA1CA2CYP1A2CYP2C19 | |
| SCHEMBL25397955 | 0.85 | PSMB5 (0.42) | POLBCA1CA2CYP1A2CYP2C19 | |
| SCHEMBL29678720 | 0.82 | CA1 (0.40) | POLBCA1CA2NPSR1LMNA | |
| SCHEMBL24517766 | 0.82 | POLB (0.51) | POLBCA1CA2NPSR1LMNA | |
| SCHEMBL24518110 | 0.81 | LMNA (0.43) | POLBCA1CA2CYP1A2CYP2C19 | |
| SCHEMBL12250264 | 0.80 | CA1 (0.40) | CA1CA2CYP1A2CYP2C19NPSR1 | |
| SCHEMBL12250262 | 0.78 | LMNA (0.38) | POLBCA1CA2CYP1A2CYP2C19 | |
| SCHEMBL24518112 | 0.78 | CA1 (0.43) | CA1CA2NPSR1LMNAKMT2A | |
| SCHEMBL25399601 | 0.69 | PSMB5 (0.46) | POLBCA1CA2CYP1A2CYP2C19 | |
| SCHEMBL25399595 | 0.69 | PSMB5 (0.46) | POLBCA1CA2CYP1A2CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010005765-A1 | METHOD OF TREATMENT AND PHARMACEUTICAL COMPOSITIONS | GILEAD SCIENCES, INC. (US) | 2010-01-14 | — | — | WO | claimed |