Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 10/20 | 0.38 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.38 |
| ▸ | FLT1 | P17948 | 2/20 | 0.37 |
| ▸ | FLT4 | P35916 | 1/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.37 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.37 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.37 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.37 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.37 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.37 |
| ▸ | PARP1 | P09874 | 5/20 | 0.37 |
| ▸ | LCK | P06239 | 2/20 | 0.37 |
| ▸ | JAK3 | P52333 | 2/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3432028 | 0.85 | AURKA (0.36) | AURKAKDRHDAC1HDAC6FLT1 | |
| SCHEMBL589192 | 0.81 | SRC (0.47) | AURKAKDRHDAC1HDAC6CYP3A4 | |
| Hydrochloric Acid SCHEMBL6995137 | 0.79 | NEK2 (0.35) | KDRHDAC1HDAC6FLT1FLT4 | |
| SCHEMBL30453745 | 0.78 | HDAC1 (0.53) | KDRHDAC1HDAC6FLT1FLT4 | |
| SCHEMBL589341 | 0.78 | HDAC1 (0.53) | KDRHDAC1HDAC6FLT1FLT4 | |
| SCHEMBL588759 | 0.76 | KDR (0.46) | AURKAKDR | |
| SCHEMBL588575 | 0.75 | KDR (0.47) | AURKAKDRHDAC1HDAC6FLT1 | |
| SCHEMBL31672523 | 0.75 | KDR (0.49) | AURKAKDRHDAC1HDAC6FLT1 | |
| SCHEMBL10151181 | 0.75 | KDR (0.49) | AURKAKDRHDAC1HDAC6FLT1 | |
| SCHEMBL10151205 | 0.74 | KDR (0.51) | AURKAKDRHDAC1HDAC6FLT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100105712-A1 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2010-04-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100105712-A1 | CHEMICAL COMPOUNDS | KDR, FLT4, FLT1 | AURKA 450/4885KDR 1/4885EPHB4 569/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.