Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 20/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3431794 | 0.91 | BRAF (0.47) | BRAF | |
| SCHEMBL1593607 | 0.89 | BRAF (0.64) | BRAF | |
| SCHEMBL1593426 | 0.81 | BRAF (0.61) | BRAF | |
| SCHEMBL1593527 | 0.80 | BRAF (0.68) | BRAF | |
| SCHEMBL3431424 | 0.76 | BRAF (0.59) | BRAF | |
| SCHEMBL1593124 | 0.74 | BRAF (0.67) | BRAF | |
| SCHEMBL1592833 | 0.71 | BRAF (0.75) | BRAF | |
| SCHEMBL3429909 | 0.71 | CYP2C19 (0.60) | BRAF | |
| SCHEMBL1593687 | 0.70 | BRAF (0.66) | BRAF | |
| SCHEMBL12703636 | 0.70 | BRAF (0.74) | BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2265610-A1 | PYRAZOLE [3, 4-B]PYRIDINE RAF INHIBITORS | Array Biopharma, Inc. (US) | 2010-12-29 | — | — | EP | disclosed |
| WO-2009111279-A1 | PYRAZOLE [3, 4-B] PYRIDINE RAF INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2009-09-11 | — | — | WO | disclosed |