Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 5/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | KDM1A | O60341 | 4/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | TYR | P14679 | 1/20 | 0.36 |
| ▸ | CA7 | P43166 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1780404 | 1.00 | HDAC1 (0.52) | HDAC1KCNH2OPRM1OPRK1HTT | |
| SCHEMBL1780403 | 1.00 | HDAC1 (0.52) | HDAC1KCNH2OPRM1OPRK1HTT | |
| SCHEMBL1780400 | 1.00 | HDAC1 (0.52) | HDAC1KCNH2OPRM1OPRK1HTT | |
| SCHEMBL1778049 | 0.92 | HDAC1 (0.61) | HDAC1KCNH2KDM1AHDAC8HDAC6 | |
| SCHEMBL1778045 | 0.92 | HDAC1 (0.61) | HDAC1KCNH2KDM1AHDAC8HDAC6 | |
| SCHEMBL3411827 | 0.92 | HDAC1 (0.61) | HDAC1KCNH2KDM1AHDAC8HDAC6 | |
| SCHEMBL1778047 | 0.92 | HDAC1 (0.61) | HDAC1KCNH2KDM1AHDAC8HDAC6 | |
| SCHEMBL3432137 | 0.84 | HDAC1 (0.50) | HDAC1KCNH2OPRM1OPRK1HTT | |
| SCHEMBL1780445 | 0.84 | HDAC1 (0.50) | HDAC1KCNH2OPRM1OPRK1HTT | |
| SCHEMBL1780451 | 0.84 | HDAC1 (0.50) | HDAC1KCNH2OPRM1OPRK1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2260020-A1 | HYDROXAMATE-BASED INHIBITORS OF DEACETYLASES B | Novartis AG (CH) | 2010-12-15 | — | — | EP | disclosed |
| WO-2009118305-A1 | HYDROXAMATE-BASED INHIBITORS OF DEACETYLASES B | NOVARTIS AG (CH) | 2009-10-01 | — | — | WO | disclosed |