Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 3/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.46 |
| ▸ | NOS2 | P35228 | 2/20 | 0.46 |
| ▸ | CASR | P41180 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2463100 | 1.00 | CYP2D6 (0.46) | CYP2D6SLC6A2SLC6A4NOS2CASR | |
| SCHEMBL2462064 | 0.84 | CASR (0.50) | SLC6A2CASRL3MBTL1HTR1AOPRM1 | |
| SCHEMBL14270043 | 0.73 | TSHR (0.43) | CYP2D6SLC6A2SLC6A4NOS2ALDH1A1 | |
| SCHEMBL14469653 | 0.73 | CASR (0.56) | CYP2D6SLC6A2SLC6A4CASRALDH1A1 | |
| SCHEMBL6187010 | 0.70 | TSHR (0.42) | CYP2D6SLC6A2SLC6A4NOS2ALDH1A1 | |
| SCHEMBL6186410 | 0.70 | TSHR (0.45) | CYP2D6SLC6A2SLC6A4NOS2ALDH1A1 | |
| SCHEMBL3130880 | 0.69 | TSHR (0.42) | CYP2D6SLC6A2SLC6A4NOS2ALDH1A1 | |
| SCHEMBL3730227 | 0.67 | CASR (0.50) | CYP2D6SLC6A2SLC6A4CASRALDH1A1 | |
| SCHEMBL3730225 | 0.67 | CASR (0.50) | CYP2D6SLC6A2SLC6A4CASRALDH1A1 | |
| SCHEMBL25265717 | 0.67 | HPGD (0.36) | CYP2D6SLC6A2SLC6A4NOS2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010042642-A1 | CALCIUM RECEPTOR MODULATING AGENTS | AMGEN INC. (US) | 2010-04-15 | — | — | WO | disclosed |