Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASR | P41180 | 13/20 | 0.50 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.44 |
| ▸ | PPARG | P37231 | 1/20 | 0.44 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.44 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.44 |
| ▸ | PLK1 | P53350 | 1/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.39 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | HRH2 | P25021 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3433090 | 0.84 | CYP2D6 (0.46) | CASRNPSR1L3MBTL1PLK1MAPT | |
| SCHEMBL2463100 | 0.84 | CYP2D6 (0.46) | CASRNPSR1L3MBTL1PLK1MAPT | |
| SCHEMBL2461100 | 0.77 | CASR (0.61) | CASRROCK2ROCK1PFKFB3HTR1A | |
| SCHEMBL2458998 | 0.74 | CASR (0.61) | CASRNPSR1HTR1AADRA2BADRA2C | |
| SCHEMBL2458679 | 0.70 | CASR (0.65) | CASRMAPTHTR1AADRA2BADRA2C | |
| SCHEMBL14540134 | 0.68 | CASR (0.70) | CASRHTR1AADRA2BADRA2CSLC6A2 | |
| SCHEMBL15131119 | 0.68 | CASR (0.70) | CASRHTR1AADRA2BADRA2CSLC6A2 | |
| SCHEMBL14282588 | 0.67 | CASR (0.68) | CASRHTR1AADRA2BADRA2CSLC6A2 | |
| SCHEMBL2219867 | 0.67 | CASR (0.59) | CASRPFKFB3HTR1AADRA2BADRA2C | |
| SCHEMBL15131118 | 0.66 | CASR (0.75) | CASRHTR1AADRA2BADRA2CSLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110230517-A1 | CALCIUM RECEPTOR MODULATING AGENTS | AMGEN INC. | 2011-09-22 | — | — | US | claimed |
| US-8791147-B2 | Calcium receptor modulating agents | AMGEN INC. (US) | 2014-07-29 | — | — | US | disclosed |
| US-8791147-B2 | Calcium receptor modulating agents | AMGEN INC. (US) | 2014-07-29 | — | — | US | disclosed |
| US-20110230517-A1 | CALCIUM RECEPTOR MODULATING AGENTS | AMGEN INC. | 2011-09-22 | — | — | US | disclosed |
| US-20110230517-A1 | CALCIUM RECEPTOR MODULATING AGENTS | AMGEN INC. | 2011-09-22 | — | — | US | disclosed |
| WO-2010042642-A1 | CALCIUM RECEPTOR MODULATING AGENTS | AMGEN INC. (US) | 2010-04-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110230517-A1 | CALCIUM RECEPTOR MODULATING AGENTS | CASR, CALCR, CNR1 | CASR 1/4885RXFP1 402/4885PPARG 1338/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.