Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.61 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | CDK1 | P06493 | 1/20 | 0.43 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | GABRA2 | P47869 | 3/20 | 0.43 |
| ▸ | GABRB2 | P47870 | 3/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA7 | P43166 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17652250 | 0.84 | CYP1A2 (0.63) | CYP1A2MAPTKMT2AGAAKDM4E | |
| SCHEMBL28430253 | 0.84 | CYP1A2 (0.54) | CYP1A2MAPTNPC1RAB9AKMT2A | |
| SCHEMBL28426558 | 0.82 | CYP1A2 (0.61) | CYP1A2MAPTNPC1RAB9AKMT2A | |
| SCHEMBL27285116 | 0.81 | CYP1A2 (0.59) | CYP1A2MAPTNPC1RAB9AKMT2A | |
| SCHEMBL2783408 | 0.81 | CYP1A2 (0.59) | CYP1A2MAPTNPC1RAB9AKMT2A | |
| SCHEMBL6197085 | 0.81 | CYP1A2 (0.51) | CYP1A2MAPTNPC1RAB9AKMT2A | |
| SCHEMBL1478915 | 0.77 | CYP1A2 (1.00) | CYP1A2MAPTNPC1RAB9AKMT2A | |
| SCHEMBL1095857 | 0.76 | CYP1A2 (0.77) | CYP1A2MAPTNPC1RAB9AKMT2A | |
| SCHEMBL31337797 | 0.76 | CYP1A2 (0.77) | CYP1A2MAPTNPC1RAB9AKMT2A | |
| SCHEMBL1725005 | 0.76 | KDM4E (0.66) | KMT2AMEN1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2265614-A1 | IMIDAZO [1,2-B]PYRIDAZINE DERIVATIVES FOR THE TREATMENT OF C-MET TYROSINE KINASE MEDIATED DISEASE | Novartis AG (CH) | 2010-12-29 | — | — | EP | disclosed |
| WO-2009106577-A1 | IMIDAZO [1,2-B] PYRIDAZINE DERIVATIVES FOR THE TREATMENT OF C-MET TYROSINE KINASE MEDIATED DISEASE | NOVARTIS AG (CH) | 2009-09-03 | — | — | WO | disclosed |