Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 2/20 | 0.40 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.40 |
| ▸ | MTOR | P42345 | 5/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 5/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.38 |
| ▸ | BIRC5 | O15392 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.36 |
| ▸ | PRKDC | P78527 | 2/20 | 0.36 |
| ▸ | ATM | Q13315 | 2/20 | 0.36 |
| ▸ | SERPINA2 | P20848 | 1/20 | 0.36 |
| ▸ | ATR | Q13535 | 2/20 | 0.35 |
| ▸ | ATRIP | Q8WXE1 | 1/20 | 0.35 |
| ▸ | PIK3C2A | O00443 | 2/20 | 0.35 |
| ▸ | PIK3C2B | O00750 | 2/20 | 0.35 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.35 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3433972 | 0.90 | PDGFRB (0.38) | PDGFRBPDGFRAMTORPIK3CAPIK3CD | |
| SCHEMBL2185317 | 0.87 | PIK3CA (0.40) | PDGFRBPDGFRAMTORPIK3CAPIK3CD | |
| SCHEMBL2184974 | 0.78 | PIK3CA (0.38) | PDGFRBPDGFRAMTORPIK3CAPIK3CD | |
| SCHEMBL2183124 | 0.77 | BIRC5 (0.38) | PDGFRBPDGFRAMTORPIK3CAPIK3CD | |
| SCHEMBL2183658 | 0.75 | PDGFRB (0.38) | PDGFRBPDGFRAMTORPIK3CAPIK3CD | |
| SCHEMBL2182391 | 0.74 | PDGFRB (0.40) | PDGFRBPDGFRAMTORPIK3CAPIK3CD | |
| SCHEMBL2181737 | 0.72 | CYP11B1 (0.42) | PDGFRBPDGFRAMTORPIK3CAPIK3CD | |
| SCHEMBL2181700 | 0.71 | HSP90AA1 (0.34) | PDGFRBPDGFRAHSP90AA1 | |
| SCHEMBL21927539 | 0.69 | ALDH1A1 (0.40) | ATMACVR1 | |
| SCHEMBL24323416 | 0.69 | KDM4E (0.43) | PIK3CDMAPTATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2265598-A2 | NOVEL HSP90 INHIBITORY CARBAZOLE DERIVATIVES, COMPOSITIONS CONTAINING SAME, AND USE THEREOF | Sanofi-Aventis (FR) | 2010-12-29 | — | — | EP | disclosed |
| WO-2009122034-A2 | NOVEL HSP90 INHIBITORY CARBAZOLE DERIVATIVES, COMPOSITIONS CONTAINING SAME, AND USE THEREOF | SANOFI-AVENTIS (FR) | 2009-10-08 | — | — | WO | disclosed |