Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.56 |
| ▸ | RAB9A | P51151 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | EGFR | P00533 | 7/20 | 0.50 |
| ▸ | PIK3CA | P42336 | 7/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | DAO | P14920 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | CCKAR | P32238 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | NHERF1 | O14745 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19476086 | 0.82 | NPC1 (0.64) | NPC1RAB9ALMNASMN1; SMN2EGFR | |
| SCHEMBL19476095 | 0.80 | NPC1 (0.58) | NPC1RAB9ALMNASMN1; SMN2EGFR | |
| SCHEMBL19476161 | 0.78 | NPC1 (0.62) | NPC1RAB9ALMNASMN1; SMN2EGFR | |
| SCHEMBL19476092 | 0.76 | NPC1 (0.59) | NPC1RAB9ALMNASMN1; SMN2EGFR | |
| SCHEMBL13701154 | 0.76 | NHERF1 (0.74) | NPC1RAB9ALMNASMN1; SMN2CCKAR | |
| SCHEMBL29630891 | 0.75 | NPC1 (0.49) | NPC1RAB9ALMNASMN1; SMN2KDM4E | |
| SCHEMBL1308155 | 0.75 | NPC1 (0.58) | NPC1RAB9ALMNASMN1; SMN2EGFR | |
| SCHEMBL19476162 | 0.74 | NPC1 (0.64) | NPC1RAB9ALMNASMN1; SMN2EGFR | |
| SCHEMBL7208136 | 0.73 | NPC1 (1.00) | NPC1RAB9ALMNASMN1; SMN2EGFR | |
| SCHEMBL29475123 | 0.73 | NPC1 (1.00) | NPC1RAB9ALMNASMN1; SMN2EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2247600-A2 | BENZOXAZOLE CARBOXAMIDE INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE (PARP) | Lead Therapeutics, Inc. (US) | 2010-11-10 | — | — | EP | disclosed |
| WO-2009099736-A2 | BENZOXAZOLE CARBOXAMIDE INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE (PARP) | LEAD THERAPEUTICS, INC. (US) | 2009-08-13 | — | — | WO | disclosed |