Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 4/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.38 |
| ▸ | CCNA2 | P20248 | 4/20 | 0.38 |
| ▸ | CDK2 | P24941 | 4/20 | 0.38 |
| ▸ | CCNA1 | P78396 | 4/20 | 0.38 |
| ▸ | GFER | P55789 | 1/20 | 0.35 |
| ▸ | F10 | P00742 | 1/20 | 0.35 |
| ▸ | MET | P08581 | 1/20 | 0.35 |
| ▸ | ROS1 | P08922 | 1/20 | 0.35 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.34 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.34 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.34 |
| ▸ | NMT1 | P30419 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7172622 | 0.90 | F10 (0.41) | RAB9ANPC1MAPTCCNA2CDK2 | |
| SCHEMBL3432471 | 0.82 | CCNA2 (0.51) | RAB9AMAPTCCNA2CDK2CCNA1 | |
| SCHEMBL2925472 | 0.79 | CDK2 (0.59) | RAB9AMAPTCCNA2CDK2CCNA1 | |
| SCHEMBL7170691 | 0.71 | MAPK1 (0.40) | ALK | |
| SCHEMBL2924190 | 0.70 | CDK2 (0.58) | MAPTCCNA2CDK2CCNA1F10 | |
| SCHEMBL2923237 | 0.70 | CCNA2 (0.46) | RAB9ANPC1MAPTCCNA2CDK2 | |
| SCHEMBL2925339 | 0.67 | CYP1A2 (0.49) | CCNA2CDK2CCNA1ALKCCNB2 | |
| SCHEMBL2920399 | 0.67 | CDK2 (0.56) | RAB9ANPC1MAPTCCNA2CDK2 | |
| SCHEMBL2957863 | 0.66 | CDK2 (0.68) | MAPTCCNA2CDK2CCNA1LMNA | |
| SCHEMBL2922601 | 0.66 | CCNA2 (0.48) | RAB9ANPC1CCNA2CDK2CCNA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4555547-B2 | — | — | 2010-10-06 | — | — | JP | claimed |
| JP-2004505977-A | — | — | 2004-02-26 | — | — | JP | claimed |
| EP-1320531-A2 | BICYCLO-PYRAZOLES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Pharmacia Italia S.p.A. (IT) | 2003-06-25 | — | — | EP | claimed |
| WO-2002012242-A2 | BICYCLO-PYRAZOLES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | PHARMACIA ITALIA S.P.A. (IT) | 2002-02-14 | — | — | WO | claimed |