Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 8/20 | 0.40 |
| ▸ | PHGDH | O43175 | 1/20 | 0.38 |
| ▸ | AURKA | O14965 | 10/20 | 0.37 |
| ▸ | AURKB | Q96GD4 | 5/20 | 0.37 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.34 |
| ▸ | RET | P07949 | 1/20 | 0.34 |
| ▸ | BCR | P11274 | 1/20 | 0.34 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2925454 | 0.79 | AURKA (0.50) | MAPK1PHGDHAURKAAURKBALK | |
| SCHEMBL2924951 | 0.78 | AURKA (0.57) | MAPK1AURKAAURKBALKABL1 | |
| SCHEMBL2925456 | 0.73 | CCNA2 (0.45) | MAPK1PHGDHAURKAAURKB | |
| SCHEMBL3434473 | 0.71 | RAB9A (0.39) | ALK | |
| SCHEMBL3432471 | 0.69 | CCNA2 (0.51) | MAPK1AURKA | |
| SCHEMBL2925406 | 0.67 | CDK2 (0.62) | MAPK1AURKAAURKBABL1BCR | |
| SCHEMBL13823555 | 0.67 | MAPT (0.54) | MAPK1 | |
| SCHEMBL2919626 | 0.66 | MAPK1 (0.60) | MAPK1AURKAAURKB | |
| SCHEMBL2924954 | 0.65 | MAPK1 (0.41) | MAPK1PHGDHAURKA | |
| SCHEMBL2915963 | 0.65 | AURKA (0.45) | MAPK1AURKAAURKBALKABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1320531-A2 | BICYCLO-PYRAZOLES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Pharmacia Italia S.p.A. (IT) | 2003-06-25 | — | — | EP | disclosed |
| WO-2002012242-A2 | BICYCLO-PYRAZOLES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | PHARMACIA ITALIA S.P.A. (IT) | 2002-02-14 | — | — | WO | disclosed |