Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 10/20 | 0.61 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | DRD2 | P14416 | 1/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | QDPR | P09417 | 1/20 | 0.46 |
| ▸ | HTR6 | P50406 | 3/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | HTR7 | P34969 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | RAD52 | P43351 | 1/20 | 0.43 |
| ▸ | KHK | P50053 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL2078358 | 1.00 | HTR2C (0.61) | HTR2CSIGMAR1ALDH1A1KDM4EMAPT | |
| SCHEMBL14540702 | 0.78 | HTR6 (0.67) | HTR2CSIGMAR1ALDH1A1KDM4EMAPT | |
| Hydrochloric Acid SCHEMBL3690362 | 0.78 | HTR2C (0.61) | HTR2CSIGMAR1ALDH1A1KDM4EMAPT | |
| Hydrochloric Acid SCHEMBL9530706 | 0.78 | HTR2C (0.61) | HTR2CSIGMAR1ALDH1A1KDM4EMAPT | |
| SCHEMBL2269949 | 0.78 | HTR2C (0.61) | HTR2CSIGMAR1ALDH1A1KDM4EMAPT | |
| SCHEMBL1106949 | 0.78 | HTR2C (0.61) | HTR2CSIGMAR1ALDH1A1KDM4EMAPT | |
| SCHEMBL4790197 | 0.78 | HTR2C (0.61) | HTR2CSIGMAR1ALDH1A1KDM4EMAPT | |
| SCHEMBL4790160 | 0.78 | HTR2C (0.61) | HTR2CSIGMAR1ALDH1A1KDM4EMAPT | |
| Hydrochloric Acid SCHEMBL21359253 | 0.78 | HTR2C (0.61) | HTR2CSIGMAR1ALDH1A1KDM4EMAPT | |
| SCHEMBL1366798 | 0.78 | HTR2C (0.61) | HTR2CSIGMAR1ALDH1A1KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8163746-B2 | Azolecarboxamide derivative | ASTELLAS PHARMA INC. (JP) | 2012-04-24 | — | — | US | disclosed |
| US-8163746-B2 | Azolecarboxamide derivative | ASTELLAS PHARMA INC. (JP) | 2012-04-24 | — | — | US | disclosed |
| US-20090286766-A1 | AZOLECARBOXAMIDE DERIVATIVE | ASTELLAS PHARMA INC. (JP) | 2009-11-19 | — | — | US | disclosed |
| US-20090286766-A1 | AZOLECARBOXAMIDE DERIVATIVE | ASTELLAS PHARMA INC. (JP) | 2009-11-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090286766-A1 | AZOLECARBOXAMIDE DERIVATIVE | GPR17, NTRK1, TRPV1 | HTR2C 1146/4885SIGMAR1 1460/4885ALDH1A1 975/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.