⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL343560 | 1.00 | — | — | |
| SCHEMBL25412343 | 1.00 | — | — | |
| SCHEMBL25411728 | 0.84 | — | — | |
| SCHEMBL25411732 | 0.84 | — | — | |
| SCHEMBL280456 | 0.67 | — | — | |
| SCHEMBL16317106 | 0.67 | — | — | |
| SCHEMBL11248490 | 0.65 | — | — | |
| SCHEMBL11957434 | 0.63 | ALDH1A1 (0.35) | — | |
| SCHEMBL17662273 | 0.63 | ALDH1A1 (0.35) | — | |
| SCHEMBL21226754 | 0.62 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1153923-B1 | Process for the preparation of N-Carboxy-t-Leucine anhydride | DSM NV (NL) | 2003-07-30 | — | — | EP | claimed |
| US-6476231-B2 | CYCLIZATION USING ACYL HALOGENIDE; CHEMICAL INTERMEDIATE | DSM N.V. (NL) | 2002-11-05 | — | — | US | claimed |
| US-20010041812-A1 | Process for the preparation of N-carboxy-t-leucine anhydride | DSM N.V. (NL) | 2001-11-15 | — | — | US | claimed |
| EP-1153923-A1 | Process for the preparation of N-Carboxy-t-Leucine anhydride | DSM N.V. (NL) | 2001-11-14 | — | — | EP | claimed |
| US-8835422-B2 | Substituted imidazoheterocycle derivatives | CARA THERAPEUTICS, INC. (US) | 2014-09-16 | — | — | US | disclosed |
| US-8835422-B2 | Substituted imidazoheterocycle derivatives | CARA THERAPEUTICS, INC. (US) | 2014-09-16 | — | — | US | disclosed |
| US-8835422-B2 | Substituted imidazoheterocycle derivatives | CARA THERAPEUTICS, INC. (US) | 2014-09-16 | — | — | US | disclosed |
| US-8431565-B2 | Substituted imidazoheterocycles | CARA THERAPEUTICS, INC. (US) | 2013-04-30 | — | — | US | disclosed |
| US-8431565-B2 | Substituted imidazoheterocycles | CARA THERAPEUTICS, INC. (US) | 2013-04-30 | — | — | US | disclosed |
| US-8431565-B2 | Substituted imidazoheterocycles | CARA THERAPEUTICS, INC. (US) | 2013-04-30 | — | — | US | disclosed |
| US-20120015930-A1 | SUBSTITUTED IMIDAZOHETEROCYCLE DERIVATIVES | CARA THERAPEUTICS, INC. (US) | 2012-01-19 | — | — | US | disclosed |
| US-20120015930-A1 | SUBSTITUTED IMIDAZOHETEROCYCLE DERIVATIVES | CARA THERAPEUTICS, INC. (US) | 2012-01-19 | — | — | US | disclosed |
| US-6476231-B2 | CYCLIZATION USING ACYL HALOGENIDE; CHEMICAL INTERMEDIATE | DSM N.V. (NL) | 2002-11-05 | — | — | US | disclosed |
| US-6476231-B2 | CYCLIZATION USING ACYL HALOGENIDE; CHEMICAL INTERMEDIATE | DSM N.V. (NL) | 2002-11-05 | — | — | US | disclosed |
| JP-2002003482-A | METHOD FOR PRODUCING N-CARBOXY-T-LEUCINE ANHYDRIDE | DSM NV | 2002-01-09 | — | — | JP | disclosed |
| US-20010041812-A1 | Process for the preparation of N-carboxy-t-leucine anhydride | DSM N.V. (NL) | 2001-11-15 | — | — | US | disclosed |
| US-20010041812-A1 | Process for the preparation of N-carboxy-t-leucine anhydride | DSM N.V. (NL) | 2001-11-15 | — | — | US | disclosed |
| US-20010041812-A1 | Process for the preparation of N-carboxy-t-leucine anhydride | DSM N.V. (NL) | 2001-11-15 | — | — | US | disclosed |
| EP-1153923-A1 | Process for the preparation of N-Carboxy-t-Leucine anhydride | DSM N.V. (NL) | 2001-11-14 | — | — | EP | disclosed |
| EP-1153923-A1 | Process for the preparation of N-Carboxy-t-Leucine anhydride | DSM N.V. (NL) | 2001-11-14 | — | — | EP | disclosed |