Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 4/20 | 0.37 |
| ▸ | KDR | P35968 | 2/20 | 0.35 |
| ▸ | FLT1 | P17948 | 1/20 | 0.35 |
| ▸ | FLT4 | P35916 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.34 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.34 |
| ▸ | KCNH3 | Q9ULD8 | 3/20 | 0.33 |
| ▸ | GSK3B | P49841 | 3/20 | 0.33 |
| ▸ | CDK2 | P24941 | 2/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.33 |
| ▸ | CDK4 | P11802 | 1/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.33 |
| ▸ | SYK | P43405 | 3/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | ZAP70 | P43403 | 2/20 | 0.32 |
| ▸ | SRC | P12931 | 1/20 | 0.32 |
| ▸ | MUSK | O15146 | 1/20 | 0.32 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3783059 | 1.00 | JAK2 (0.37) | JAK2KDRFLT1FLT4MAPK1 | |
| SCHEMBL3776106 | 0.90 | SRC (0.33) | MAPK1LMNATP53ZAP70SRC | |
| SCHEMBL3435554 | 0.90 | SRC (0.33) | MAPK1LMNATP53ZAP70SRC | |
| SCHEMBL3777850 | 0.89 | GSK3B (0.46) | JAK2KDRFLT1FLT4GSK3B | |
| SCHEMBL8018216 | 0.89 | GSK3B (0.46) | JAK2KDRFLT1FLT4GSK3B | |
| SCHEMBL3434426 | 0.85 | MAPK1 (0.33) | JAK2MAPK1GSK3BCDK2CDK4 | |
| SCHEMBL3781770 | 0.85 | MAPK1 (0.33) | JAK2MAPK1GSK3BCDK2CDK4 | |
| SCHEMBL3779354 | 0.80 | SRC (0.33) | MAPK1LMNASRC | |
| SCHEMBL3781782 | 0.78 | MAPK1 (0.33) | MAPK1CDK2CDK4P2RX7 | |
| SCHEMBL3030101 | 0.78 | JAK2 (0.42) | JAK2KDRFLT1FLT4PTK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2257535-A1 | TRISUBSTITUTED 1, 2, 4 -TRIAZOIIES AS NICOTINIC ACETYLCHOLINE RECEPTOR MODULATORS | Janssen Pharmaceutica N.V. (BE) | 2010-12-08 | — | — | EP | disclosed |
| WO-2009115547-A1 | TRISUBSTITUTED 1, 2, 4 -TRIAZOIIES AS NICOTINIC ACETYLCHOLINE RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2009-09-24 | — | — | WO | disclosed |