Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 7/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | IGF1R | P08069 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | PRKCQ | Q04759 | 3/20 | 0.31 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | PDE2A | O00408 | 1/20 | 0.30 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.30 |
| ▸ | KARS1 | Q15046 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3776106 | 1.00 | SRC (0.33) | SRCLMNATP53MAPTIGF1R | |
| SCHEMBL3435660 | 0.90 | JAK2 (0.37) | SRCLMNATP53MAPK1ZAP70 | |
| SCHEMBL3783059 | 0.90 | JAK2 (0.37) | SRCLMNATP53MAPK1ZAP70 | |
| SCHEMBL3779354 | 0.89 | SRC (0.33) | SRCLMNAMAPTIGF1RSMN1; SMN2 | |
| SCHEMBL3770357 | 0.83 | RAPGEF4 (0.30) | — | |
| SCHEMBL3433367 | 0.83 | RAPGEF4 (0.30) | — | |
| SCHEMBL3777850 | 0.78 | GSK3B (0.46) | SRCZAP70 | |
| SCHEMBL3026142 | 0.77 | LMNA (0.35) | SRCLMNATP53MAPTSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL3021462 | 0.77 | LMNA (0.34) | SRCLMNATP53MAPTSMN1; SMN2 | |
| SCHEMBL3431969 | 0.75 | TP53 (0.31) | TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2257535-A1 | TRISUBSTITUTED 1, 2, 4 -TRIAZOIIES AS NICOTINIC ACETYLCHOLINE RECEPTOR MODULATORS | Janssen Pharmaceutica N.V. (BE) | 2010-12-08 | — | — | EP | disclosed |
| WO-2009115547-A1 | TRISUBSTITUTED 1, 2, 4 -TRIAZOIIES AS NICOTINIC ACETYLCHOLINE RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2009-09-24 | — | — | WO | disclosed |