Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 1/20 | 0.49 |
| ▸ | MMP9 | P14780 | 2/20 | 0.49 |
| ▸ | MMP1 | P03956 | 1/20 | 0.49 |
| ▸ | MMP3 | P08254 | 1/20 | 0.49 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.49 |
| ▸ | ADAM9 | Q13443 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | GRIN2B | Q13224 | 4/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | JAK2 | O60674 | 2/20 | 0.44 |
| ▸ | JAK1 | P23458 | 2/20 | 0.44 |
| ▸ | TYK2 | P29597 | 2/20 | 0.44 |
| ▸ | JAK3 | P52333 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10154348 | 0.84 | LCK (0.54) | LCKSMN1; SMN2NPC1RAB9AGRIN2B | |
| SCHEMBL22869197 | 0.82 | SMN1; SMN2 (0.56) | LCKSMN1; SMN2NPC1RAB9AGRIN2B | |
| SCHEMBL4144887 | 0.80 | SMN1; SMN2 (0.51) | LCKSMN1; SMN2NPC1RAB9AGRIN2B | |
| SCHEMBL1320424 | 0.79 | SMN1; SMN2 (0.58) | LCKSMN1; SMN2NPC1RAB9AGRIN2B | |
| SCHEMBL3272711 | 0.79 | SMN1; SMN2 (0.58) | LCKSMN1; SMN2NPC1RAB9AGRIN2B | |
| SCHEMBL3277927 | 0.79 | SMN1; SMN2 (0.58) | LCKSMN1; SMN2NPC1RAB9AGRIN2B | |
| SCHEMBL5368184 | 0.78 | ALDH1A1 (0.56) | LCKSMN1; SMN2NPC1RAB9AGRIN2B | |
| SCHEMBL2499417 | 0.78 | SMN1; SMN2 (0.56) | LCKSMN1; SMN2NPC1RAB9AGRIN2B | |
| SCHEMBL1843641 | 0.78 | SMN1; SMN2 (0.56) | LCKSMN1; SMN2NPC1RAB9AGRIN2B | |
| SCHEMBL8696423 | 0.78 | SMN1; SMN2 (0.56) | LCKMMP3SMN1; SMN2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2262802-A1 | PIM KINASE INHIBITORS AND METHODS OF THEIR USE | Novartis AG (CH) | 2010-12-22 | — | — | EP | disclosed |
| WO-2009109576-A1 | PIM KINASE INHIBITORS AND METHODS OF THEIR USE | NOVARTIS AG (CH) | 2009-09-11 | — | — | WO | disclosed |