Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 10/20 | 0.50 |
| ▸ | KIF20A | O95235 | 8/20 | 0.50 |
| ▸ | CLK1 | P49759 | 9/20 | 0.43 |
| ▸ | CLK2 | P49760 | 2/20 | 0.36 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.36 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.36 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.35 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.32 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | GUSB | P08236 | 1/20 | 0.30 |
| ▸ | THRA | P10827 | 1/20 | 0.30 |
| ▸ | THRB | P10828 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2725443 | 0.87 | DYRK1A (0.65) | DYRK1AKIF20ACLK1CLK2CLK4 | |
| SCHEMBL3433137 | 0.81 | DYRK1A (0.75) | DYRK1AKIF20ACLK1CLK2CLK4 | |
| SCHEMBL3433140 | 0.81 | DYRK1A (0.75) | DYRK1AKIF20ACLK1CLK2CLK4 | |
| SCHEMBL2726582 | 0.77 | DYRK1A (0.68) | DYRK1AKIF20ACLK1CLK2CLK4 | |
| SCHEMBL2726580 | 0.77 | DYRK1A (0.68) | DYRK1AKIF20ACLK1CLK2CLK4 | |
| SCHEMBL3434437 | 0.72 | DYRK1A (0.38) | DYRK1AKIF20ACLK1 | |
| SCHEMBL13016173 | 0.71 | DYRK1A (0.78) | DYRK1AKIF20ACLK1CLK2CLK4 | |
| SCHEMBL2728064 | 0.71 | DYRK1A (0.80) | DYRK1AKIF20ACLK1CLK2CLK4 | |
| SCHEMBL2728069 | 0.71 | DYRK1A (0.80) | DYRK1AKIF20ACLK1CLK2CLK4 | |
| SCHEMBL2726414 | 0.71 | DYRK1A (0.80) | DYRK1AKIF20ACLK1CLK2CLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2266562-A1 | Use of derivatives of indoles for the treatment of cancer | Centre National de la Recherche Scientifique (FR) | 2010-12-29 | — | — | EP | claimed |