Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.71 |
| ▸ | MEN1 | O00255 | 4/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.71 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.71 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.71 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.71 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.71 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.71 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.71 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.71 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.71 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.71 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.71 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.71 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.71 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.71 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.71 |
| ▸ | TP53 | P04637 | 1/20 | 0.71 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.71 |
| ▸ | HTR1A | P08908 | 1/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3436021 | 0.95 | MAPT (0.79) | MAPTMEN1KMT2AADRA1ACYP1A2 | |
| SCHEMBL3434608 | 0.94 | MAPT (0.76) | MAPTMEN1KMT2AADRA1ACYP1A2 | |
| SCHEMBL10889767 | 0.91 | MAPT (0.71) | MAPTMEN1KMT2AADRA1ACYP1A2 | |
| SCHEMBL11682220 | 0.90 | MAPT (0.70) | MAPTMEN1KMT2AADRA1ACYP1A2 | |
| SCHEMBL7289675 | 0.89 | ADRA1A (0.73) | MAPTMEN1KMT2AADRA1ACYP1A2 | |
| SCHEMBL7436653 | 0.89 | MAPT (0.73) | MAPTMEN1KMT2AADRA1ACYP1A2 | |
| SCHEMBL10366027 | 0.88 | ABCB1 (0.73) | MAPTMEN1KMT2AADRA1ACYP1A2 | |
| SCHEMBL3435123 | 0.88 | ADRA1A (0.68) | MAPTMEN1KMT2AADRA1ACYP1A2 | |
| SCHEMBL9381507 | 0.88 | ADRA1A (0.91) | MAPTMEN1KMT2AADRA1ACYP1A2 | |
| SCHEMBL7343603 | 0.88 | MAPT (0.70) | MAPTMEN1KMT2AADRA1ACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8163907-B2 | Dihydropyridine calcium antagonist compounds, preparation methods, and medical uses thereof | COSUNTER PHARMACEUTICAL COMPANY (CN) | 2012-04-24 | — | — | US | disclosed |
| US-8163907-B2 | Dihydropyridine calcium antagonist compounds, preparation methods, and medical uses thereof | COSUNTER PHARMACEUTICAL COMPANY (CN) | 2012-04-24 | — | — | US | disclosed |
| US-20110201811-A1 | DIHYDROPYRIDINE CALCIUM ANTAGONIST COMPOUNDS, PREPARATION METHODS, AND MEDICAL USES THEREOF | COSUNTER PHARMACEUTICAL COMPANY (CN) | 2011-08-18 | — | — | US | disclosed |
| US-20110201811-A1 | DIHYDROPYRIDINE CALCIUM ANTAGONIST COMPOUNDS, PREPARATION METHODS, AND MEDICAL USES THEREOF | COSUNTER PHARMACEUTICAL COMPANY (CN) | 2011-08-18 | — | — | US | disclosed |
| US-5137889-A | Hypotensive agents; coronary vasodilators; calcium antagonists; antiinflammatory agents | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1992-08-11 | — | — | US | disclosed |
| US-5034395-A | Hypotensive agents, carboxylated dihydropyridines | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1991-07-23 | — | — | US | disclosed |
| EP-0145434-A2 | Novel dihydropyridine derivatives and process for preparing the same | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1985-06-19 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110201811-A1 | DIHYDROPYRIDINE CALCIUM ANTAGONIST COMPOUNDS, PREPARATION METHODS, AND MEDICAL USES THEREOF | RYR1, CACNA1E, CACNA1C | MAPT 3963/4885MEN1 434/4885KMT2A 3869/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.