Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC16A3 | O15427 | 1/20 | 0.45 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.36 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.35 |
| ▸ | FEN1 | P39748 | 1/20 | 0.34 |
| ▸ | RBP4 | P02753 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | HTR2B | P41595 | 1/20 | 0.33 |
| ▸ | ELANE | P08246 | 1/20 | 0.33 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | SSTR1 | P30872 | 1/20 | 0.33 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10202901 | 0.88 | SLC16A3 (0.43) | SLC16A3CNR1CNR2KDM4ES1PR1 | |
| SCHEMBL16215627 | 0.87 | SLC16A3 (0.41) | SLC16A3CNR1CNR2KDM4ES1PR1 | |
| SCHEMBL15677639 | 0.85 | SLC16A3 (0.41) | SLC16A3CNR1CNR2KDM4ES1PR1 | |
| SCHEMBL14678665 | 0.76 | KDM4E (0.39) | SLC16A3CNR1CNR2KDM4EFEN1 | |
| SCHEMBL8414862 | 0.75 | CNR1 (0.48) | CNR1CNR2KDM4ESMN1; SMN2 | |
| SCHEMBL14892448 | 0.74 | KDM4E (0.41) | SLC16A3CNR1CNR2KDM4EFEN1 | |
| SCHEMBL5009531 | 0.73 | L3MBTL1 (0.45) | CNR1CNR2KDM4EFEN1HTR2A | |
| SCHEMBL29585194 | 0.73 | KDM4E (0.41) | CNR1CNR2KDM4EFEN1HTR2A | |
| SCHEMBL17910321 | 0.73 | KDM4E (0.41) | CNR1CNR2KDM4EFEN1HTR2A | |
| SCHEMBL1695382 | 0.73 | CYP1A2 (0.43) | SLC16A3CNR1CNR2KDM4EFEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2464645-B1 | FUSED HETEROCYCLIC COMPOUNDS AS ION CHANNEL MODULATORS | GILEAD SCIENCES INC (US) | 2017-07-05 | — | — | EP | disclosed |
| US-8952034-B2 | Fused heterocyclic compounds as ion channel modulators | GILEAD SCIENCES, INC. (US) | 2015-02-10 | — | — | US | disclosed |
| US-8754103-B2 | — | — | 2014-06-17 | — | — | US | disclosed |
| WO-2012003392-A1 | FUSED HETEROCYCLIC COMPOUNDS AS ION CHANNEL MODULATORS | GILEAD SCIENCES, INC. (US) | 2012-01-05 | — | — | WO | disclosed |