Sugi Predict

Sugi Predict / Compounds / SCHEMBL343636

SCHEMBL343636

SCHEMBL343636

COC(=O)C(N)COC(C)(C)C

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MAPK1 P28482 1/20 0.41
▸ CA1 P00915 1/20 0.34
▸ CA2 P00918 1/20 0.34
▸ KIF11 P52732 1/20 0.34
▸ SMN1; SMN2 Q16637 2/20 0.33
▸ GRN P28799 1/20 0.33
▸ SORT1 Q99523 1/20 0.33
▸ CA12 O43570 1/20 0.32
▸ CA14 Q9ULX7 1/20 0.32
▸ P2RY10 O00398 1/20 0.31
▸ GPR174 Q9BXC1 1/20 0.31
▸ BACE1 P56817 1/20 0.31
▸ ALDH1A1 P00352 1/20 0.31
▸ HRH2 P25021 1/20 0.30
▸ HRH1 P35367 1/20 0.30
▸ DGAT1 O75907 1/20 0.30
▸ GRIN2D O15399 1/20 0.30
▸ GRIN3B O60391 1/20 0.30
▸ GRIN1 Q05586 1/20 0.30
▸ GRIN2A Q12879 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1588396 1.00 MAPK1 (0.41) MAPK1CA1CA2KIF11SMN1; SMN2
SCHEMBL343637 1.00 MAPK1 (0.41) MAPK1CA1CA2KIF11SMN1; SMN2
Hydrochloric Acid SCHEMBL29401055 0.98 MAPK1 (0.40) MAPK1CA1CA2KIF11SMN1; SMN2
Hydrochloric Acid SCHEMBL241035 0.98 MAPK1 (0.40) MAPK1CA1CA2KIF11SMN1; SMN2
Hydrochloric Acid SCHEMBL1304617 0.98 MAPK1 (0.40) MAPK1CA1CA2KIF11SMN1; SMN2
SCHEMBL3080102 0.83 MAPK1 (0.41) MAPK1CA1CA2GRNSORT1
SCHEMBL522783 0.83 MAPK1 (0.41) MAPK1CA1CA2GRNSORT1
SCHEMBL522812 0.83 MAPK1 (0.41) MAPK1CA1CA2GRNSORT1
Hydrochloric Acid SCHEMBL318950 0.82 MAPK1 (0.40) MAPK1CA1CA2HRH2HRH1
Hydrochloric Acid SCHEMBL522782 0.82 MAPK1 (0.40) MAPK1CA1CA2HRH2HRH1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 39 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260062378-A1 O-TERT-BUTYL-L-SERYL-O-TERT-BUTYL-L-SERYL-GLYCINE AND PREPARATION METHOD THEREOF SICHUAN SHIFANG SANGAO BIOCHEMICAL INDUSTRIAL CO., LTD. (CN) 2026-03-05 — — US claimed
CN-113135842-A Preparation method of O-tert-butyl-L-serine methyl ester and O-tert-butyl-L-serine aqueous solution 四川什邡市三高生化实业有限公司 2021-07-20 — — CN claimed
CN-104163848-A Synthetic method of dipeptide Fmoc-Ser(tBu)-Cys-OH SUZHOU VIVOTIDE BIOTECHNOLOGIES CO LTD 2014-11-26 — — CN claimed
CN-101284803-A Synthetic method of N-fluorenylmethoxycarbonyl-O-tert-butyl serine GL BIOCHEM SHANGHAI LTD (CN) 2008-10-15 — — CN claimed
US-20260062378-A1 O-TERT-BUTYL-L-SERYL-O-TERT-BUTYL-L-SERYL-GLYCINE AND PREPARATION METHOD THEREOF SICHUAN SHIFANG SANGAO BIOCHEMICAL INDUSTRIAL CO., LTD. (CN) 2026-03-05 — — US disclosed
US-20260062378-A1 O-TERT-BUTYL-L-SERYL-O-TERT-BUTYL-L-SERYL-GLYCINE AND PREPARATION METHOD THEREOF SICHUAN SHIFANG SANGAO BIOCHEMICAL INDUSTRIAL CO., LTD. (CN) 2026-03-05 — — US disclosed
CN-119080874-A O-tert-butyl-L-seryl-glycine and preparation method thereof 四川什邡市三高生化实业有限公司 2024-12-06 — — CN disclosed
CN-119080874-A O-tert-butyl-L-seryl-glycine and preparation method thereof 四川什邡市三高生化实业有限公司 2024-12-06 — — CN disclosed
CN-109928971-B Aryl substituted aminotetrahydropyrans and uses thereof 广东东阳光药业股份有限公司 2024-01-16 — — CN disclosed
WO-2023212549-A1 TRICYCLIC PYRIDONES AND PYRIMIDONES ERASCA, INC. (US) 2023-11-02 — — WO disclosed
CN-113135842-A Preparation method of O-tert-butyl-L-serine methyl ester and O-tert-butyl-L-serine aqueous solution 四川什邡市三高生化实业有限公司 2021-07-20 — — CN disclosed
CN-113135842-A Preparation method of O-tert-butyl-L-serine methyl ester and O-tert-butyl-L-serine aqueous solution 四川什邡市三高生化实业有限公司 2021-07-20 — — CN disclosed
WO-2010007027-A1 SELECTIVE HYDROXAMIC ACID BASED MMP-12 AND MMP-13 INHIBITORS NOVARTIS AG (CH) 2010-01-21 — — WO disclosed
US-7531545-B2 2-amino-3,4-dihydro-pyrido[3,4-d]pyrimidine derivatives useful as inhibitors of β-secretase (BACE) JANSSEN PHARMACEUTICA, N.V. (BE) 2009-05-12 — — US disclosed
CN-101284803-A Synthetic method of N-fluorenylmethoxycarbonyl-O-tert-butyl serine GL BIOCHEM SHANGHAI LTD (CN) 2008-10-15 — — CN disclosed
CN-101284803-A Synthetic method of N-fluorenylmethoxycarbonyl-O-tert-butyl serine GL BIOCHEM SHANGHAI LTD (CN) 2008-10-15 — — CN disclosed
EP-1966198-A1 2-AMINO-3,4-DIHYDRO-PYRIDOÝ3,4-D¨PYRIMIDINE DERIVATIVES USEFUL AS INHIBITORS OF BETA-SECRETASE (BACE) JANSSEN PHARMACEUTICA N.V. (BE) 2008-09-10 — — EP disclosed
US-20070259898-A1 NOVEL 2-AMINO-3,4-DIHYDRO-PYRIDO[3,4-D]PYRIMIDINE DERIVATIVES USEFUL AS INHIBITORS OF beta-SECRETASE (BACE) BAXTER ELLEN E 2007-11-08 — — US disclosed
WO-2007050612-A1 2-AMINO-3,4-DIHYDRO-PYRIDO[3,4-D]PYRIMIDINE DERIVATIVES USEFUL AS INHIBITORS OF BETA-SECRETASE (BACE) JANSSEN PHARMACEUTICA N.V. (BE) 2007-05-03 — — WO disclosed
US-4081530-A Extended chain derivatives of somatostatin AYERST, MCKENNA & HARRISON LIMITED (CA) 1978-03-28 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070259898-A1 NOVEL 2-AMINO-3,4-DIHYDRO-PYRIDO[3,4-D]PYRIMIDINE DERIVATIVES USEFUL AS INHIBITORS OF beta-SECRETASE (BACE) BACE2, PSEN2, BACE1 MAPK1 4255/4885CA1 3872/4885CA2 2372/4885
US-20260062378-A1 O-TERT-BUTYL-L-SERYL-O-TERT-BUTYL-L-SERYL-GLYCINE AND PREPARATION METHOD THEREOF MGMT, TERT, SPTSSB MAPK1 2167/4885CA1 1867/4885CA2 2071/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.