Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.66 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.62 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.62 |
| ▸ | TSHR | P16473 | 1/20 | 0.61 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.61 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.60 |
| ▸ | ATM | Q13315 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.55 |
| ▸ | APEX1 | P27695 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7325326 | 0.89 | ALDH1A1 (0.68) | ALDH1A1TDP1CYP1A2CYP2C19TSHR | |
| SCHEMBL3369076 | 0.86 | KMT2A (0.63) | ALDH1A1CYP1A2CYP2C19POLBKMT2A | |
| SCHEMBL31619840 | 0.86 | KMT2A (0.63) | ALDH1A1CYP1A2CYP2C19POLBKMT2A | |
| SCHEMBL15315085 | 0.85 | TSHR (0.60) | ALDH1A1CYP1A2CYP2C19TSHRMAPK10 | |
| SCHEMBL6289156 | 0.82 | ALDH1A1 (0.73) | ALDH1A1TDP1EPHX2ATMPOLB | |
| SCHEMBL6289157 | 0.82 | ALDH1A1 (0.73) | ALDH1A1TDP1EPHX2ATMPOLB | |
| SCHEMBL7025629 | 0.81 | MCL1 (0.64) | ALDH1A1TSHREPHX2POLBKMT2A | |
| SCHEMBL12989739 | 0.81 | ALDH1A1 (0.71) | ALDH1A1TDP1EPHX2ATMPOLB | |
| SCHEMBL6317352 | 0.81 | MCL1 (0.64) | ALDH1A1TSHREPHX2POLBKMT2A | |
| SCHEMBL29213174 | 0.81 | ALDH1A1 (0.71) | ALDH1A1TDP1TSHRMAPK10EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100331549-A1 | Novel compounds useful for modulating abnormal cell proliferation | ROIFMAN CHAIM | 2010-12-30 | — | — | US | disclosed |
| US-20100331549-A1 | Novel compounds useful for modulating abnormal cell proliferation | ROIFMAN CHAIM | 2010-12-30 | — | — | US | disclosed |
| US-20100331549-A1 | Novel compounds useful for modulating abnormal cell proliferation | ROIFMAN CHAIM | 2010-12-30 | — | — | US | disclosed |
| US-7807719-B2 | Compounds useful for modulating abnormal cell proliferation | Roifman, Chaim (CA) | 2010-10-05 | — | — | US | disclosed |
| US-7807719-B2 | Compounds useful for modulating abnormal cell proliferation | Roifman, Chaim (CA) | 2010-10-05 | — | — | US | disclosed |
| US-7807719-B2 | Compounds useful for modulating abnormal cell proliferation | Roifman, Chaim (CA) | 2010-10-05 | — | — | US | disclosed |
| US-7598419-B2 | Compounds for modulating cell proliferation | HSC RESEARCH AND DEVELOPMENT LIMITED PARTNERSHIP (CA) | 2009-10-06 | — | — | US | disclosed |
| US-7598419-B2 | Compounds for modulating cell proliferation | HSC RESEARCH AND DEVELOPMENT LIMITED PARTNERSHIP (CA) | 2009-10-06 | — | — | US | disclosed |
| EP-1797064-A4 | NOVEL COMPOUNDS USEFUL FOR MODULATING ABNORMAL CELL PROLIFERATION | HOSPITAL FOR SICK CHILDREN (CA) | 2009-06-24 | — | — | EP | disclosed |
| US-20070243612-A1 | Novel Compounds for Modulating Cell Proliferation | HSC RESEARCH AND DEVELOPMENT LIMITED PARTNERSHIP (CA) | 2007-10-18 | — | — | US | disclosed |
| WO-2005092904-A1 | NOVEL COMPOUNDS FOR MODULATING CELL PROLIFERATION | HSC RESEARCH AND DEVELOPMENT LIMITED PARTNERSHIP (CA) | 2005-10-06 | — | — | WO | disclosed |
| EP-1551381-A2 | STYRYLACRYLONITRILE COMPOUNDS FOR INHIBITION OF VASCULAR ENDOTHELIAL GROWTH FACTOR | The Hospital for Sick Children (CA) | 2005-07-13 | — | — | EP | disclosed |
| US-20050059657-A1 | Aminoisoxazole derivatives active as kinase inhibitors | PFIZER ITALIA S.R.L. (IT) | 2005-03-17 | — | — | US | disclosed |
| US-20040209845-A1 | Novel compounds for modulating cell proliferation | HSC RESEARCH AND DEVELOPMENT LIMITED PARTNERSHIP (CA) | 2004-10-21 | — | — | US | disclosed |
| US-6800659-B2 | NOVEL STYRYLACRYLONITRILE COMPOUNDS WHICH ARE USEFUL IN TREATING A VARIETY OF CELL PROLIFERATIVE DISORDERS SUCH AS CANCER ARE DISCLOSED. A METHOD OF MODULATING CELL PROLIFERATION COMPRISING ADMINISTERING AN EFFECTIVE AMOUNT OF | HSC RESEARCH AND DEVELOPMENT LIMITED PARTNERSHIP (CA) | 2004-10-05 | — | — | US | disclosed |
| WO-2004032911-A2 | STYRYLACRYLONITRILE COMPOUNDS FOR INHIBITION OF VASCULAR ENDOTHELIAL GROWTH FACTOR | THE HOSPITAL FOR SICK CHILDREN (CA) | 2004-04-22 | — | — | WO | disclosed |
| US-20040072803-A1 | Novel compounds for modulating cell proliferation | HSC RESEARCH AND DEVELOPMENT LIMITED (CA) | 2004-04-15 | — | — | US | disclosed |
| US-20030109502-A1 | Novel compounds for modulating cell proliferation | HSC RESEARCH AND DEVELOPMENT LIMITED PARTNERSHIP (CA) | 2003-06-12 | — | — | US | disclosed |
| EP-1272457-A2 | COMPOUNDS FOR MODULATING CELL PROLIFERATION | HSC Research and Development Limited Partnership (CA) | 2003-01-08 | — | — | EP | disclosed |
| WO-2001079158-A2 | COMPOUNDS FOR MODULATING CELL PROLIFERATION | HSC RESEARCH AND DEVELOPMENT LIMITED PARTNERSHIP (CA) | 2001-10-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050059657-A1 | Aminoisoxazole derivatives active as kinase inhibitors | MAP3K9, MAP3K19, MAP4K2 | ALDH1A1 4444/4885TDP1 527/4885CYP1A2 4402/4885 |
| US-20070243612-A1 | Novel Compounds for Modulating Cell Proliferation | MKI67, CCNA1, PCNA | ALDH1A1 546/4885TDP1 2605/4885CYP1A2 4684/4885 |
| US-20040209845-A1 | Novel compounds for modulating cell proliferation | MKI67, CCNA1, CCNI | ALDH1A1 178/4885TDP1 2317/4885CYP1A2 4071/4885 |
| US-20030109502-A1 | Novel compounds for modulating cell proliferation | MKI67, CCNA1, CCNI | ALDH1A1 178/4885TDP1 2317/4885CYP1A2 4071/4885 |
| US-20100331549-A1 | Novel compounds useful for modulating abnormal cell proliferation | MKI67, CALU, CDK4 | ALDH1A1 1908/4885TDP1 2776/4885CYP1A2 4044/4885 |
| US-20040072803-A1 | Novel compounds for modulating cell proliferation | MKI67, CCNA1, MCL1 | ALDH1A1 179/4885TDP1 2120/4885CYP1A2 3874/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.