Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | TAOK1 | Q7L7X3 | 2/20 | 0.44 |
| ▸ | TAOK3 | Q9H2K8 | 1/20 | 0.44 |
| ▸ | XIAP | P98170 | 2/20 | 0.44 |
| ▸ | BIRC3 | Q13489 | 2/20 | 0.44 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.44 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.44 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.44 |
| ▸ | AADAT | Q8N5Z0 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10066056 | 0.91 | XIAP (0.48) | ALDH1A1LMNAMAPTKCNH2XIAP | |
| SCHEMBL10081804 | 0.89 | XIAP (0.57) | XIAPBIRC3 | |
| SCHEMBL3439205 | 0.88 | XIAP (0.45) | ALDH1A1LMNAMAPTKCNH2HTT | |
| SCHEMBL10066059 | 0.88 | XIAP (0.46) | ALDH1A1LMNAMAPTTAOK1TAOK3 | |
| SCHEMBL10066053 | 0.87 | KCNH2 (0.46) | ALDH1A1LMNAMAPTKCNH2XIAP | |
| SCHEMBL13119037 | 0.87 | XIAP (0.45) | ALDH1A1LMNAMAPTHTTXIAP | |
| SCHEMBL10081370 | 0.87 | XIAP (0.47) | XIAPBIRC3 | |
| SCHEMBL895174 | 0.86 | XIAP (0.44) | ALDH1A1LMNAMAPTXIAPBIRC3 | |
| SCHEMBL3439008 | 0.85 | XIAP (0.52) | ALDH1A1LMNAMAPTXIAPBIRC3 | |
| SCHEMBL896276 | 0.84 | BIRC2 (0.42) | ALDH1A1LMNAMAPTKCNH2XIAP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130281385-A1 | SMALL MOLECULE APOPTOSIS PROMOTERS | JOYANT PHARMACEUTICALS, INC. | 2013-10-24 | — | — | US | disclosed |
| US-8222291-B2 | Small molecule apoptosis promoters | JOYANT PHARMACEUTICALS, INC. (US) | 2012-07-17 | — | — | US | disclosed |
| US-7807699-B2 | Dimeric pyrrolidine amide-containing small molecule apoptosis promoters | JOYANT PHARMACEUTICALS, INC. (US) | 2010-10-05 | — | — | US | disclosed |
| EP-1996184-A2 | SMALL MOLECULE APOPTOSIS PROMOTERS | Joyant Pharmaceuticals, Inc. (US) | 2008-12-03 | — | — | EP | disclosed |
| US-20080051389-A1 | Small molecule apoptosis promoters | JOYANT PHARMACEUTICALS, INC. | 2008-02-28 | — | — | US | disclosed |
| WO-2007136921-A2 | SMALL MOLECULE APOPTOSIS PROMOTERS | JOYANT PHARMACEUTICALS, INC. (US) | 2007-11-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130281385-A1 | SMALL MOLECULE APOPTOSIS PROMOTERS | BID, BAD, BAX | ALDH1A1 4619/4885LMNA 685/4885MAPT 3392/4885 |
| US-20080051389-A1 | Small molecule apoptosis promoters | BID, BAD, BAX | ALDH1A1 4619/4885LMNA 685/4885MAPT 3392/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.