SCHEMBL344059

SCHEMBL344059

ClCOCCOCc1ccccc1

nearest known ligand 0.61

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
TSHR P16473 1/20 0.61
NAAA Q02083 1/20 0.50
IDO1 P14902 1/20 0.44
LTA4H P09960 1/20 0.43
AGXT P21549 1/20 0.43
TDP1 Q9NUW8 1/20 0.42
L3MBTL1 Q9Y468 1/20 0.42
ALDH1A1 P00352 1/20 0.42
CA1 P00915 2/20 0.41
CA2 P00918 2/20 0.41
CA7 P43166 2/20 0.41
CA9 Q16790 2/20 0.41
KDM4E B2RXH2 1/20 0.41
POLB P06746 1/20 0.41
HTT P42858 1/20 0.41
SMN1; SMN2 Q16637 1/20 0.41
HRH4 Q9H3N8 1/20 0.41
HRH3 Q9Y5N1 1/20 0.41
TACR1 P25103 2/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25310046 0.91 TSHR (0.56) TSHRNAAAIDO1LTA4HAGXT
SCHEMBL19520 0.88 TSHR (0.70) TSHRIDO1AGXTALDH1A1CA1
SCHEMBL1991359 0.88 TSHR (0.78) TSHRNAAAIDO1LTA4HAGXT
SCHEMBL30397113 0.86 TSHR (0.67) TSHRNAAAIDO1AGXTALDH1A1
SCHEMBL10660158 0.86 TSHR (0.67) TSHRNAAAIDO1AGXTALDH1A1
Phosphine SCHEMBL7705717 0.86 TSHR (0.67) TSHRNAAAIDO1AGXTALDH1A1
SCHEMBL4608747 0.85 TSHR (0.74) TSHRNAAAIDO1LTA4HAGXT
SCHEMBL9505432 0.85 TSHR (0.74) TSHRNAAAIDO1LTA4HAGXT
SCHEMBL10895400 0.85 TSHR (0.74) TSHRNAAAIDO1LTA4HAGXT
SCHEMBL26189828 0.85 TSHR (0.74) TSHRNAAAIDO1LTA4HAGXT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 40 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119110793-A Fluorine-containing ether compound, lubricant for magnetic recording medium, and magnetic recording medium 株式会社力森诺科 2024-12-10 CN disclosed
US-RE46234-E1 Tissue adhesive and sealant comprising polyglycerol aldehyde ACTAMAX SURGICAL MATERIALS, LLC (US) 2016-12-13 US disclosed
EP-2411062-B1 TISSUE ADHESIVE AND SEALANT COMPRISING POLYGLYCEROL ALDEHYDE ACTAMAX SURGICAL MATERIALS LLC (US) 2014-08-20 EP disclosed
US-8680200-B2 Polyglycerol aldehydes ACTAMAX SURGICAL MATERIALS LLC (US) 2014-03-25 US disclosed
US-8404779-B2 Tissue adhesive and sealant comprising polyglycerol aldehyde ACTAMAX SURGICAL MATERIALS LLC (US) 2013-03-26 US disclosed
EP-2411448-B1 POLYGLYCEROL ALDEHYDES ACTAMAX SURGICAL MATERIALS LLC (US) 2013-03-20 EP disclosed
US-8334320-B2 Methods for chelation therapy UNIVERSITY OF UTAH RESEARCH FOUNDATION (US) 2012-12-18 US disclosed
US-20120029149-A1 POLYGLYCEROL ALDEHYDES ACTAMAX SURGICAL MATERIALS, LLC (US) 2012-02-02 US disclosed
EP-2411448-A1 POLYGLYCEROL ALDEHYDES Actamax Surgical Materials LLC (US) 2012-02-01 EP disclosed
EP-2411062-A1 TISSUE ADHESIVE AND SEALANT COMPRISING POLYGLYCEROL ALDEHYDE Actamax Surgical Materials LLC (US) 2012-02-01 EP disclosed
EP-0452680-A1 Substituted purines, process for their preparation and their use as antiviral agents HOECHST AKTIENGESELLSCHAFT (DE) 1991-10-23 EP disclosed
EP-0193347-B1 13-SUBSTITUTED DERIVATIVES OF AVERMECTIN AGLYCONES MERCK & CO. INC. (US) 1990-08-29 EP disclosed
EP-0201166-B1 ERYTHROMYCIN DERIVATIVES BEECHAM GROUP PLC (GB) 1990-02-07 EP disclosed
US-4847242-A ANTIBIOTICS BEECHAM GROUP P.L.C. (GB) 1989-07-11 US disclosed
US-4801710-A Regioselective synthesis of 9-substituted purine acyclonucleoside derivatives MERCK & CO., INC. (US) 1989-01-31 US disclosed
EP-0193347-A2 13-Substituted derivatives of avermectin aglycones MERCK & CO. INC. (US) 1986-09-03 EP disclosed
EP-0184473-A1 Regioselective synthesis of 9-substituted purine acyclonucleoside derivatives MERCK & CO. INC. (US) 1986-06-11 EP disclosed
US-4587247-A ANTHELMINTIC, PARASITICIDES MERCK & CO., INC. (US) 1986-05-06 US disclosed
EP-0158513-A2 Antiviral compounds THE WELLCOME FOUNDATION LIMITED (GB) 1985-10-16 EP disclosed
US-4225706-A Polychalcogen ester of cephem compound, process for preparing the same and method for removing the protective group of the same MEIJI SEIKA KAISHA LTD. (JP) 1980-09-30 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120029149-A1 POLYGLYCEROL ALDEHYDES GGH, TGM3, FABP2 TSHR 4315/4885NAAA 491/4885IDO1 1979/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.