Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 3/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | BRD4 | O60885 | 4/20 | 0.43 |
| ▸ | BAZ2A | Q9UIF9 | 2/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | PTGER4 | P35408 | 5/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.39 |
| ▸ | ACSS2 | Q9NR19 | 1/20 | 0.39 |
| ▸ | PDE6D | O43924 | 1/20 | 0.38 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.38 |
| ▸ | PDE4A | P27815 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL980644 | 0.81 | KDM4E (0.69) | MAPK1KDM4EALDH1A1LMNAHPGD | |
| SCHEMBL983125 | 0.80 | ACSS2 (0.49) | MAPK1KDM4EALDH1A1LMNAHPGD | |
| SCHEMBL982527 | 0.78 | MAPK1 (0.66) | MAPK1KDM4EALDH1A1LMNAHPGD | |
| SCHEMBL31300308 | 0.76 | KDM4E (0.63) | MAPK1KDM4EALDH1A1LMNAHPGD | |
| SCHEMBL981898 | 0.74 | KDM4E (1.00) | MAPK1KDM4EALDH1A1LMNAHPGD | |
| SCHEMBL983242 | 0.71 | KDM4E (0.49) | MAPK1KDM4EALDH1A1LMNAHPGD | |
| SCHEMBL980698 | 0.68 | PDE4A (0.54) | MAPK1KDM4EALDH1A1LMNAHPGD | |
| SCHEMBL31448372 | 0.68 | CFTR (0.52) | KDM4EALDH1A1HPGDHSD17B10BRD4 | |
| SCHEMBL16872617 | 0.67 | KDM4E (0.73) | MAPK1KDM4EALDH1A1LMNAHPGD | |
| SCHEMBL18731913 | 0.67 | CNR2 (0.48) | MAPK1KDM4EALDH1A1BRD4BAZ2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2247580-A1 | QUINOXALINONE DERIVATIVES AS INSULIN SECRETION STIMULATORS, METHODS FOR OBTAINING THEM AND USE THEREOF FOR THE TREATMENT OF DIABETES | Merck Patent GmbH (DE) | 2010-11-10 | — | — | EP | disclosed |
| WO-2009109258-A1 | QUINOXALINONE DERIVATIVES AS INSULIN SECRETION STIMULATORS, METHODS FOR OBTAINING THEM AND USE THEREOF FOR THE TREATMENT OF DIABETES | MERCK PATENT GMBH (DE) | 2009-09-11 | — | — | WO | disclosed |