Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 6/20 | 0.66 |
| ▸ | HTT | P42858 | 4/20 | 0.56 |
| ▸ | GAA | P10253 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.53 |
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | THRB | P10828 | 1/20 | 0.52 |
| ▸ | EGFR | P00533 | 1/20 | 0.50 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20598033 | 0.89 | FFAR4 (0.61) | LMNAHTTGAAKDM4ENPC1 | |
| SCHEMBL28282858 | 0.82 | SMN1; SMN2 (0.63) | LMNAHTTGAAKDM4ENPC1 | |
| SCHEMBL28000002 | 0.77 | HTT (0.67) | HTTKDM4ENPC1TSHRALDH1A1 | |
| SCHEMBL1179791 | 0.76 | HTT (0.65) | HTTKDM4ENPC1TSHRALDH1A1 | |
| SCHEMBL28137220 | 0.76 | HTT (0.65) | HTTKDM4ENPC1KMT2ATSHR | |
| SCHEMBL16235273 | 0.76 | TSHR (0.74) | LMNAHTTGAAKDM4ENPC1 | |
| SCHEMBL12306892 | 0.75 | ALDH1A1 (0.87) | LMNAHTTKDM4ETDP1KMT2A | |
| SCHEMBL8067186 | 0.75 | SLC7A11 (0.77) | LMNAHTTGAAKDM4ENPC1 | |
| SCHEMBL30772996 | 0.75 | HTT (0.71) | LMNAHTTKDM4ENPC1TSHR | |
| SCHEMBL9502644 | 0.75 | HTT (0.71) | HTTKDM4ENPC1KMT2ATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8293892-B2 | Substituted tetrahydropyrazolo-pyrido-azepine compounds | ARQULE, INC. (US) | 2012-10-23 | — | — | US | disclosed |
| US-8293892-B2 | Substituted tetrahydropyrazolo-pyrido-azepine compounds | ARQULE, INC. (US) | 2012-10-23 | — | — | US | disclosed |
| US-8293892-B2 | Substituted tetrahydropyrazolo-pyrido-azepine compounds | ARQULE, INC. (US) | 2012-10-23 | — | — | US | disclosed |
| EP-2414358-A1 | SUBSTITUTED TETRAHYDROPYRAZOLO-PYRIDO-AZEPIN COMPOUNDS | ArQule, Inc. (US) | 2012-02-08 | — | — | EP | disclosed |
| US-20120015935-A1 | Substituted Tetrahydropyrazolo-Pyrido-Azepine Compounds | ARQULE, INC. (US) | 2012-01-19 | — | — | US | disclosed |
| US-20120015935-A1 | Substituted Tetrahydropyrazolo-Pyrido-Azepine Compounds | ARQULE, INC. (US) | 2012-01-19 | — | — | US | disclosed |
| US-20120015935-A1 | Substituted Tetrahydropyrazolo-Pyrido-Azepine Compounds | ARQULE, INC. (US) | 2012-01-19 | — | — | US | disclosed |
| US-8049005-B2 | Substituted tetrahydropyrazolo-pyrido-azepine compounds | ARQULE, INC. (US) | 2011-11-01 | — | — | US | disclosed |
| US-8049005-B2 | Substituted tetrahydropyrazolo-pyrido-azepine compounds | ARQULE, INC. (US) | 2011-11-01 | — | — | US | disclosed |
| US-8049005-B2 | Substituted tetrahydropyrazolo-pyrido-azepine compounds | ARQULE, INC. (US) | 2011-11-01 | — | — | US | disclosed |
| WO-2010114902-A1 | SUBSTITUTED TETRAHYDROPYRAZOLO-PYRIDO-AZEPIN COMPOUNDS | ARQULE, INC. (US) | 2010-10-07 | — | — | WO | disclosed |
| US-20100249109-A1 | SUBSTITUTED TETRAHYDROPYRAZOLO-PYRIDO-AZEPINE COMPOUNDS | ARQULE, INC. (US) | 2010-09-30 | — | — | US | disclosed |
| US-20100249109-A1 | SUBSTITUTED TETRAHYDROPYRAZOLO-PYRIDO-AZEPINE COMPOUNDS | ARQULE, INC. (US) | 2010-09-30 | — | — | US | disclosed |
| US-20100249109-A1 | SUBSTITUTED TETRAHYDROPYRAZOLO-PYRIDO-AZEPINE COMPOUNDS | ARQULE, INC. (US) | 2010-09-30 | — | — | US | disclosed |
| EP-0804440-B1 | TRICYCLIC BENZAZEPINE VASOPRESSIN ANTAGONISTS | WYETH CORP (US) | 2007-12-19 | — | — | EP | disclosed |
| US-5719278-A | TREATING EXCESS RENAL REABSORPTION OF WATER | AMERICAN CYANAMID COMPANY (US) | 1998-02-17 | — | — | US | disclosed |
| EP-0804440-A1 | TRICYCLIC BENZAZEPINE VASOPRESSIN ANTAGONISTS | American Cyanamid Company (US) | 1997-11-05 | — | — | EP | disclosed |
| WO-1996022295-A9 | TRICYCLIC BENZAZEPINE VASOPRESSIN ANTAGONISTS | — | 1996-11-14 | — | — | WO | disclosed |
| WO-1996022295-A1 | TRICYCLIC BENZAZEPINE VASOPRESSIN ANTAGONISTS | AMERICAN CYANAMID COMPANY (US) | 1996-07-25 | — | — | WO | disclosed |
| US-5532235-A | TO TREAT EXCESS RENAL REABSORPTION | AMERICAN CYANAMID COMPANY (US) | 1996-07-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100249109-A1 | SUBSTITUTED TETRAHYDROPYRAZOLO-PYRIDO-AZEPINE COMPOUNDS | MKI67, THPO, DPYD | LMNA 3634/4885HTT 1630/4885GAA 2395/4885 |
| US-20120015935-A1 | Substituted Tetrahydropyrazolo-Pyrido-Azepine Compounds | MKI67, THPO, DPYD | LMNA 3634/4885HTT 1630/4885GAA 2395/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.