Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 8/20 | 0.47 |
| ▸ | CDK1 | P06493 | 3/20 | 0.47 |
| ▸ | CDK9 | P50750 | 2/20 | 0.44 |
| ▸ | BCDIN3D | Q7Z5W3 | 8/20 | 0.41 |
| ▸ | CCNE1 | P24864 | 5/20 | 0.41 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.39 |
| ▸ | CCNE2 | O96020 | 3/20 | 0.39 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.39 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3445582 | 0.92 | BCDIN3D (0.50) | CDK2CDK1BCDIN3DCCNE1CDK5 | |
| SCHEMBL3445297 | 0.90 | BCDIN3D (0.46) | CDK2CDK1CDK9BCDIN3DCCNE1 | |
| SCHEMBL3446859 | 0.88 | CDK2 (0.44) | CDK2CDK1CDK9BCDIN3DCCNE1 | |
| SCHEMBL3444468 | 0.86 | FLT3 (0.47) | CDK2CDK1CDK9BCDIN3DCCNE1 | |
| SCHEMBL3444370 | 0.85 | CDK2 (0.54) | CDK2CDK1CDK9CCNE1CDK5 | |
| SCHEMBL3444366 | 0.85 | CDK2 (0.54) | CDK2CDK1CDK9CCNE1CDK5 | |
| SCHEMBL3445110 | 0.84 | CDK2 (0.55) | CDK2CDK1CDK9CCNE1CDK5 | |
| SCHEMBL6203983 | 0.84 | KMT2A (0.42) | CDK1BCDIN3DCDK5 | |
| SCHEMBL3444838 | 0.83 | CDK2 (0.45) | CDK2CDK1CDK9CCNE1CDK5 | |
| SCHEMBL3446716 | 0.82 | CDK2 (0.67) | CDK2CDK1CDK9CCNE1CDK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7816350-B2 | Substituted [1,2,3] triazolo[4,5-D]pyrimidines as cdk inhibitors | INSTITUTE OF EXPERIMENTAL BOTANY ASCR (CZ) | 2010-10-19 | — | — | US | claimed |