SCHEMBL3445015

SCHEMBL3445015

CC(=O)Oc1ccccc1CNc1nc(NCC(C)N)nc2c1nnn2C(C)C

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CDK2 P24941 13/20 0.43
CCNE1 P24864 10/20 0.43
CCNE2 O96020 3/20 0.43
CCNA2 P20248 3/20 0.43
CCNA1 P78396 3/20 0.43
CDK5 Q00535 6/20 0.42
CDK5R1 Q15078 5/20 0.42
CCNT1 O60563 5/20 0.42
CDK9 P50750 5/20 0.42
CDK7 P50613 2/20 0.38
CCNH P51946 2/20 0.38
POLB P06746 1/20 0.38
CDK1 P06493 5/20 0.37
CCNB2 O95067 1/20 0.37
CCNB1 P14635 1/20 0.37
CCNB3 Q8WWL7 1/20 0.37
MAPT P10636 2/20 0.35
CCNT2 O60583 1/20 0.35
KDM4E B2RXH2 1/20 0.35
NPC1 O15118 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3446366 0.92 CDK2 (0.46) CDK2CCNE1CCNE2CCNA2CCNA1
SCHEMBL3446876 0.90 POLB (0.46) CDK2CCNE1CCNE2CCNA2CCNA1
SCHEMBL3445266 0.89 CDK2 (0.40) CDK2CCNE1CCNE2CCNA2CCNA1
SCHEMBL3445903 0.84 CDK2 (0.43) CDK2CCNE1CCNE2CCNA2CCNA1
SCHEMBL3446344 0.84 CDK1 (0.52) CDK2CCNE1CCNA2CCNA1CDK5
SCHEMBL3446341 0.84 CDK1 (0.52) CDK2CCNE1CCNA2CCNA1CDK5
SCHEMBL3444622 0.84 CDK2 (0.53) CDK2CCNE1CCNE2CCNA2CCNA1
SCHEMBL3446834 0.83 CDK2 (0.54) CDK2CCNE1CCNE2CCNA2CCNA1
SCHEMBL3446104 0.83 CDK2 (0.51) CDK2CCNE1CCNE2CCNA2CCNA1
SCHEMBL3444995 0.83 CCNE1 (0.51) CDK2CCNE1CCNE2CCNA2CCNA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7816350-B2 Substituted [1,2,3] triazolo[4,5-D]pyrimidines as cdk inhibitors INSTITUTE OF EXPERIMENTAL BOTANY ASCR (CZ) 2010-10-19 US claimed