Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 7/20 | 0.40 |
| ▸ | CCNE1 | P24864 | 5/20 | 0.40 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.40 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.40 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.40 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.40 |
| ▸ | CDK9 | P50750 | 2/20 | 0.40 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.40 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | JAK3 | P52333 | 3/20 | 0.37 |
| ▸ | JAK1 | P23458 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | BCDIN3D | Q7Z5W3 | 1/20 | 0.36 |
| ▸ | CDK7 | P50613 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3445451 | 0.92 | CDK2 (0.43) | CDK2CCNE1CCNT1CDK9CDK5 | |
| SCHEMBL3446876 | 0.90 | POLB (0.46) | CDK2CCNE1CCNE2CCNA2CCNA1 | |
| SCHEMBL3445015 | 0.89 | CDK2 (0.43) | CDK2CCNE1CCNE2CCNA2CCNA1 | |
| SCHEMBL3445734 | 0.85 | CDK1 (0.49) | CDK2CCNE1CCNE2CCNA2CCNA1 | |
| SCHEMBL3445739 | 0.85 | CDK1 (0.49) | CDK2CCNE1CCNE2CCNA2CCNA1 | |
| SCHEMBL3446713 | 0.85 | CDK2 (0.41) | CDK2CCNE1CCNE2CCNA2CCNA1 | |
| SCHEMBL3446533 | 0.84 | CDK2 (0.49) | CDK2CCNE1CCNE2CCNA2CCNA1 | |
| SCHEMBL3445813 | 0.84 | CDK2 (0.50) | CDK2CCNE1CCNE2CCNA2CCNA1 | |
| SCHEMBL3446781 | 0.83 | CCNE1 (0.51) | CDK2CCNE1CCNE2CCNA2CCNA1 | |
| SCHEMBL3444960 | 0.82 | CDK2 (0.49) | CDK2CCNE1CCNE2CCNA2CCNA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7816350-B2 | Substituted [1,2,3] triazolo[4,5-D]pyrimidines as cdk inhibitors | INSTITUTE OF EXPERIMENTAL BOTANY ASCR (CZ) | 2010-10-19 | — | — | US | claimed |