Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNE1 | P24864 | 19/20 | 0.48 |
| ▸ | CDK2 | P24941 | 19/20 | 0.48 |
| ▸ | CDK1 | P06493 | 7/20 | 0.48 |
| ▸ | CCNE2 | O96020 | 11/20 | 0.47 |
| ▸ | CCNA2 | P20248 | 8/20 | 0.47 |
| ▸ | CCNA1 | P78396 | 8/20 | 0.47 |
| ▸ | CCNB2 | O95067 | 2/20 | 0.44 |
| ▸ | CDK4 | P11802 | 2/20 | 0.44 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.44 |
| ▸ | CCND1 | P24385 | 2/20 | 0.44 |
| ▸ | CCNB3 | Q8WWL7 | 2/20 | 0.44 |
| ▸ | FLT3 | P36888 | 1/20 | 0.44 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.43 |
| ▸ | CDK9 | P50750 | 2/20 | 0.43 |
| ▸ | CDK7 | P50613 | 1/20 | 0.43 |
| ▸ | CCNH | P51946 | 1/20 | 0.43 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.43 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.43 |
| ▸ | PRKCA | P17252 | 1/20 | 0.42 |
| ▸ | CCNT2 | O60583 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3444528 | 0.90 | CDK2 (0.47) | CCNE1CDK2CDK1CCNE2CCNA2 | |
| SCHEMBL3446059 | 0.89 | CCNE1 (0.51) | CCNE1CDK2CDK1CCNE2CCNA2 | |
| SCHEMBL3445803 | 0.86 | BCDIN3D (0.49) | CCNE1CDK2CDK1CCNE2CCNA2 | |
| SCHEMBL3446265 | 0.85 | CDK2 (0.65) | CCNE1CDK2CDK1CCNE2CCNA2 | |
| SCHEMBL3446709 | 0.84 | CCNE1 (0.52) | CCNE1CDK2CDK1CCNE2CCNA2 | |
| SCHEMBL3444437 | 0.82 | CDK2 (0.65) | CCNE1CDK2CDK1CCNE2CCNA2 | |
| SCHEMBL3445888 | 0.82 | CCNE1 (0.52) | CCNE1CDK2CDK1CCNE2CCNA2 | |
| SCHEMBL3444270 | 0.81 | CDK2 (0.45) | CCNE1CDK2CDK1CCNE2CCNA2 | |
| SCHEMBL3444865 | 0.80 | CCNE1 (0.51) | CCNE1CDK2CDK1CCNE2CCNA2 | |
| SCHEMBL3445525 | 0.80 | BCDIN3D (0.44) | CCNE1CDK2CCNE2CCNA2CCNA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7816350-B2 | Substituted [1,2,3] triazolo[4,5-D]pyrimidines as cdk inhibitors | INSTITUTE OF EXPERIMENTAL BOTANY ASCR (CZ) | 2010-10-19 | — | — | US | claimed |