Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 20/20 | 0.65 |
| ▸ | CCNE1 | P24864 | 19/20 | 0.65 |
| ▸ | CDK1 | P06493 | 6/20 | 0.65 |
| ▸ | CCNE2 | O96020 | 13/20 | 0.52 |
| ▸ | CCNA2 | P20248 | 11/20 | 0.52 |
| ▸ | CCNA1 | P78396 | 10/20 | 0.52 |
| ▸ | CDK4 | P11802 | 2/20 | 0.49 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.49 |
| ▸ | CCND1 | P24385 | 2/20 | 0.49 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.49 |
| ▸ | FLT3 | P36888 | 1/20 | 0.49 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.49 |
| ▸ | CCNT1 | O60563 | 4/20 | 0.48 |
| ▸ | CDK9 | P50750 | 4/20 | 0.48 |
| ▸ | CCNT2 | O60583 | 2/20 | 0.48 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.46 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.46 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.46 |
| ▸ | CDK7 | P50613 | 1/20 | 0.46 |
| ▸ | CCNH | P51946 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3446655 | 0.89 | CDK2 (0.63) | CDK2CCNE1CDK1CCNE2CCNA2 | |
| SCHEMBL3446748 | 0.88 | CDK2 (0.62) | CDK2CCNE1CDK1CCNE2CCNA2 | |
| SCHEMBL3444437 | 0.87 | CDK2 (0.65) | CDK2CCNE1CDK1CCNE2CCNA2 | |
| SCHEMBL3445150 | 0.85 | CCNE1 (0.48) | CDK2CCNE1CDK1CCNE2CCNA2 | |
| SCHEMBL3444797 | 0.85 | CDK2 (0.51) | CDK2CCNE1CDK1CCNE2CCNA2 | |
| SCHEMBL3444248 | 0.84 | CDK2 (0.51) | CDK2CCNE1CDK1CCNE2CCNA2 | |
| SCHEMBL3445797 | 0.83 | CCNE1 (0.70) | CDK2CCNE1CDK1CCNE2CCNA2 | |
| SCHEMBL3446709 | 0.81 | CCNE1 (0.52) | CDK2CCNE1CDK1CCNE2CCNA2 | |
| SCHEMBL3444865 | 0.81 | CCNE1 (0.51) | CDK2CCNE1CDK1CCNE2CCNA2 | |
| SCHEMBL3444687 | 0.80 | CCNE1 (0.60) | CDK2CCNE1CDK1CCNE2CCNA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7816350-B2 | Substituted [1,2,3] triazolo[4,5-D]pyrimidines as cdk inhibitors | INSTITUTE OF EXPERIMENTAL BOTANY ASCR (CZ) | 2010-10-19 | — | — | US | claimed |