SCHEMBL3445309

SCHEMBL3445309

CCC(CO)Nc1nc(NCc2ccc(Cl)c(N)c2)c2nnn(C)c2n1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CDK2 P24941 10/20 0.52
CCNE1 P24864 7/20 0.52
CDK1 P06493 11/20 0.51
CCNA2 P20248 4/20 0.51
CCNA1 P78396 4/20 0.51
CCNK O75909 5/20 0.50
CDK12 Q9NYV4 5/20 0.50
CCNB1 P14635 5/20 0.49
CCNB2 O95067 3/20 0.49
CCNB3 Q8WWL7 3/20 0.49
CACNA1B Q00975 2/20 0.49
BCDIN3D Q7Z5W3 1/20 0.48
CDK7 P50613 5/20 0.47
CDK9 P50750 4/20 0.47
CDK5 Q00535 4/20 0.47
CDK4 P11802 3/20 0.47
CCND1 P24385 3/20 0.47
MAPK1 P28482 3/20 0.47
CCNH P51946 3/20 0.47
CSNK1D P48730 2/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3446887 0.90 CDK2 (0.51) CDK2CCNE1CDK1CCNA2CCNA1
SCHEMBL3445110 0.90 CDK2 (0.55) CDK2CCNE1CDK1CCNA2CCNA1
SCHEMBL3444763 0.88 CDK2 (0.54) CDK2CCNE1CDK1CCNA2CCNA1
SCHEMBL3444769 0.88 CDK2 (0.54) CDK2CCNE1CDK1CCNA2CCNA1
SCHEMBL3445600 0.85 CDK5 (0.50) CDK2CCNE1CDK1CCNA2CCNA1
SCHEMBL3445053 0.84 CDK2 (0.49) CDK2CCNE1CDK1CCNA2CCNA1
SCHEMBL3445313 0.83 CDK2 (0.71) CDK2CCNE1CDK1CCNA2CCNA1
SCHEMBL3445297 0.83 BCDIN3D (0.46) CDK2CCNE1CDK1BCDIN3DCDK9
SCHEMBL3446034 0.82 CDK2 (0.50) CDK2CCNE1CDK1CCNA2CCNA1
SCHEMBL3446124 0.82 CDK2 (0.49) CDK2CCNE1CDK1CCNA2CCNA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7816350-B2 Substituted [1,2,3] triazolo[4,5-D]pyrimidines as cdk inhibitors INSTITUTE OF EXPERIMENTAL BOTANY ASCR (CZ) 2010-10-19 US claimed