Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Diethylamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.55 |
| ▸ | DRD4 | P21917 | 4/20 | 0.53 |
| ▸ | DRD2 | P14416 | 3/20 | 0.53 |
| ▸ | DRD3 | P35462 | 3/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.51 |
| ▸ | CASP3 | P42574 | 1/20 | 0.51 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.51 |
| ▸ | RELA | Q04206 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.51 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.51 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.51 |
| ▸ | LTA4H | P09960 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL257325 | 0.90 | MEN1 (0.58) | MEN1KMT2ADRD4DRD2DRD3 | |
| Dimethylamine SCHEMBL3444783 | 0.88 | MEN1 (0.58) | MEN1KMT2ADRD4DRD2DRD3 | |
| Ammonia Solution, Strong SCHEMBL9482064 | 0.88 | MEN1 (0.57) | MEN1KMT2ADRD4DRD2DRD3 | |
| SCHEMBL9702794 | 0.84 | MEN1 (0.58) | MEN1KMT2ADRD4DRD2DRD3 | |
| SCHEMBL3790721 | 0.81 | NPC1 (0.61) | MEN1KMT2ADRD4DRD2DRD3 | |
| Diethylamine SCHEMBL1284722 | 0.81 | TDP1 (0.55) | MEN1KMT2ASMN1; SMN2LMNANPC1 | |
| Dimethylamine SCHEMBL3444887 | 0.80 | DRD4 (0.56) | MEN1KMT2ADRD4DRD2DRD3 | |
| 1,4-Dipropoxybenzene SCHEMBL122039 | 0.78 | LTA4H (0.67) | MEN1KMT2ASMN1; SMN2LMNANPC1 | |
| SCHEMBL6907235 | 0.78 | NR5A1 (0.62) | DRD4DRD2DRD3SMN1; SMN2NPC1 | |
| SCHEMBL21567534 | 0.77 | NPC1 (0.62) | MEN1KMT2ASMN1; SMN2LMNANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7816475-B2 | Aminoalkoxystyrene, process for preparation thereof, polymer thereof, process for producing the polymer and use thereof | TOSOH CORPORATION (JP) | 2010-10-19 | — | — | US | disclosed |
| EP-1829857-B1 | Aminoalkoxystyrene, process for preparation thereof, polymer thereof, process for producing the polymer and use thereof | TOSOH CORP (JP) | 2009-11-04 | — | — | EP | disclosed |
| US-20070213490-A1 | Aminoalkoxystyrene, process for preparation thereof, polymer thereof, process for producing the polymer and use thereof | TOSOH CORPORATION | 2007-09-13 | — | — | US | disclosed |
| EP-1829857-A1 | Aminoalkoxystyrene, process for preparation thereof, polymer thereof, process for producing the polymer and use thereof | Tosoh Corporation (JP) | 2007-09-05 | — | — | EP | disclosed |