Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Diethylamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.43 |
| ▸ | HTR2B | P41595 | 1/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Diethylamine SCHEMBL3445441 | 0.98 | KMT2A (0.46) | CYP1A2CYP2C9CYP2C19SMN1; SMN2KMT2A | |
| Diethylamine SCHEMBL3445435 | 0.95 | CYP1A2 (0.49) | CYP1A2CYP2C9CYP2C19SMN1; SMN2KMT2A | |
| SCHEMBL924662 | 0.92 | CYP1A2 (0.50) | CYP1A2CYP2C9CYP2C19SMN1; SMN2KMT2A | |
| Diethylamine SCHEMBL3445008 | 0.90 | ALDH1A1 (0.46) | CYP1A2CYP2C9CYP2C19SMN1; SMN2KMT2A | |
| Dimethylamine SCHEMBL3445651 | 0.90 | CYP1A2 (0.46) | CYP1A2CYP2C9CYP2C19SMN1; SMN2KMT2A | |
| SCHEMBL5562266 | 0.90 | KMT2A (0.51) | CYP1A2CYP2C9CYP2C19SMN1; SMN2KMT2A | |
| SCHEMBL2097272 | 0.90 | KMT2A (0.51) | CYP1A2CYP2C9CYP2C19SMN1; SMN2KMT2A | |
| SCHEMBL7540395 | 0.90 | KMT2A (0.51) | CYP1A2CYP2C9CYP2C19SMN1; SMN2KMT2A | |
| SCHEMBL7535277 | 0.90 | KMT2A (0.51) | CYP1A2CYP2C9CYP2C19SMN1; SMN2KMT2A | |
| SCHEMBL28035361 | 0.90 | KMT2A (0.51) | CYP1A2CYP2C9CYP2C19SMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7816475-B2 | Aminoalkoxystyrene, process for preparation thereof, polymer thereof, process for producing the polymer and use thereof | TOSOH CORPORATION (JP) | 2010-10-19 | — | — | US | disclosed |
| EP-1829857-B1 | Aminoalkoxystyrene, process for preparation thereof, polymer thereof, process for producing the polymer and use thereof | TOSOH CORP (JP) | 2009-11-04 | — | — | EP | disclosed |
| US-20070213490-A1 | Aminoalkoxystyrene, process for preparation thereof, polymer thereof, process for producing the polymer and use thereof | TOSOH CORPORATION | 2007-09-13 | — | — | US | disclosed |
| EP-1829857-A1 | Aminoalkoxystyrene, process for preparation thereof, polymer thereof, process for producing the polymer and use thereof | Tosoh Corporation (JP) | 2007-09-05 | — | — | EP | disclosed |