Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB4 | P30926 | 4/20 | 0.66 |
| ▸ | CHRNA3 | P32297 | 4/20 | 0.66 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.52 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.52 |
| ▸ | NOS3 | P29474 | 2/20 | 0.46 |
| ▸ | NOS1 | P29475 | 2/20 | 0.46 |
| ▸ | NOS2 | P35228 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.42 |
| ▸ | PNMT | P11086 | 1/20 | 0.42 |
| ▸ | KDM1A | O60341 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5768825 | 0.90 | CHRNB4 (0.59) | CHRNB4CHRNA3CHRNB2CHRNA4NOS3 | |
| Hydrochloric Acid SCHEMBL6391714 | 0.89 | CHRNB4 (0.60) | CHRNB4CHRNA3CHRNB2CHRNA4NOS3 | |
| SCHEMBL29761230 | 0.79 | CHRNB4 (1.00) | CHRNB4CHRNA3CHRNB2CHRNA4 | |
| SCHEMBL2062764 | 0.79 | CHRNB4 (1.00) | CHRNB4CHRNA3CHRNB2CHRNA4 | |
| SCHEMBL5769693 | 0.79 | CHRNB4 (0.82) | CHRNB4CHRNA3CHRNB2CHRNA4NOS3 | |
| Hydrochloric Acid SCHEMBL6392984 | 0.78 | CHRNB4 (0.82) | CHRNB4CHRNA3CHRNB2CHRNA4NOS3 | |
| SCHEMBL2062444 | 0.78 | CHRNB4 (0.60) | CHRNB4CHRNA3CHRNB2CHRNA4LMNA | |
| Hydrochloric Acid SCHEMBL4405952 | 0.78 | CHRNB4 (1.00) | CHRNB4CHRNA3CHRNB2CHRNA4 | |
| SCHEMBL6391337 | 0.77 | CHRNB4 (0.59) | CHRNB4CHRNA3CHRNB2CHRNA4LMNA | |
| Hydrochloric Acid SCHEMBL6390312 | 0.76 | CHRNB4 (0.60) | CHRNB4CHRNA3CHRNB2CHRNA4LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7816356-B2 | Aryl and heteroaryltetrahydrocyclobutapyrroles as nicotinic acetylcholine receptor ligands | YOHANNES DANIEL | 2010-10-19 | — | — | US | claimed |
| US-20050182063-A1 | Aryl and heteroaryltetrahydrocyclobutapyrroles as nicotinic acetylcholine receptor ligands | YOHANNES DANIEL (US) | 2005-08-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050182063-A1 | Aryl and heteroaryltetrahydrocyclobutapyrroles as nicotinic acetylcholine receptor ligands | OPRL1, OPRK1, CHRNB4 | CHRNB4 3/4885CHRNA3 12/4885CHRNB2 7/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.