Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 5/20 | 0.53 |
| ▸ | CDK1 | P06493 | 4/20 | 0.49 |
| ▸ | CDK2 | P24941 | 2/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | CDK9 | P50750 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.40 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.39 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | MERTK | Q12866 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.39 |
| ▸ | BCDIN3D | Q7Z5W3 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3446201 | 0.89 | FLT3 (0.68) | FLT3CDK1CDK2MAPTCDK9 | |
| SCHEMBL3446110 | 0.89 | FLT3 (0.59) | FLT3CDK1CDK2CDK9MEN1 | |
| SCHEMBL3446162 | 0.89 | CCNE2 (0.46) | FLT3CDK2TP53MAPTMEN1 | |
| SCHEMBL3445747 | 0.88 | CDK1 (0.55) | FLT3CDK1CDK2TP53MAPT | |
| SCHEMBL3445068 | 0.88 | FLT3 (0.54) | FLT3CDK1CDK2TP53MAPT | |
| SCHEMBL3445051 | 0.86 | FLT3 (0.52) | FLT3CDK1CDK2TP53MAPT | |
| SCHEMBL3446716 | 0.86 | CDK2 (0.67) | CDK1CDK2MAPTCDK9CDK5 | |
| SCHEMBL3446241 | 0.82 | CDK1 (0.51) | FLT3CDK1CDK2CDK5CCNB1 | |
| SCHEMBL3444468 | 0.82 | FLT3 (0.47) | FLT3CDK1CDK2CDK9CDK5 | |
| SCHEMBL3445890 | 0.82 | FLT3 (0.47) | FLT3CDK1CDK2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7816350-B2 | Substituted [1,2,3] triazolo[4,5-D]pyrimidines as cdk inhibitors | INSTITUTE OF EXPERIMENTAL BOTANY ASCR (CZ) | 2010-10-19 | — | — | US | claimed |