Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 7/20 | 0.68 |
| ▸ | CDK2 | P24941 | 4/20 | 0.48 |
| ▸ | CCNE2 | O96020 | 2/20 | 0.48 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.48 |
| ▸ | CDK1 | P06493 | 5/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | CDK9 | P50750 | 1/20 | 0.38 |
| ▸ | BCDIN3D | Q7Z5W3 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3444630 | 0.89 | FLT3 (0.54) | FLT3CDK2CCNE2CCNE1CDK1 | |
| SCHEMBL3446110 | 0.89 | FLT3 (0.59) | FLT3CDK2CDK1KDM4EMEN1 | |
| SCHEMBL3445929 | 0.89 | FLT3 (0.53) | FLT3CDK2CDK1MEN1MAPT | |
| SCHEMBL3445732 | 0.88 | FLT3 (0.66) | FLT3CDK2CCNE2CCNE1CDK1 | |
| SCHEMBL3444510 | 0.86 | FLT3 (0.64) | FLT3CDK2CCNE2CCNE1CDK1 | |
| SCHEMBL3444468 | 0.82 | FLT3 (0.47) | FLT3CDK2CCNE2CCNE1CDK1 | |
| SCHEMBL3445890 | 0.82 | FLT3 (0.47) | FLT3CDK2CCNE2CCNE1CDK1 | |
| SCHEMBL3445747 | 0.82 | CDK1 (0.55) | FLT3CDK2CCNE2CCNE1CDK1 | |
| SCHEMBL3445781 | 0.81 | CDK1 (0.69) | CDK2CCNE2CCNE1CDK1KDM4E | |
| SCHEMBL3445779 | 0.81 | CDK1 (0.69) | CDK2CCNE2CCNE1CDK1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7816350-B2 | Substituted [1,2,3] triazolo[4,5-D]pyrimidines as cdk inhibitors | INSTITUTE OF EXPERIMENTAL BOTANY ASCR (CZ) | 2010-10-19 | — | — | US | claimed |