Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 2/20 | 0.52 |
| ▸ | MGLL | Q99685 | 2/20 | 0.50 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.50 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.49 |
| ▸ | FEN1 | P39748 | 1/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 5/20 | 0.48 |
| ▸ | EPAS1 | Q99814 | 5/20 | 0.48 |
| ▸ | CNR2 | P34972 | 3/20 | 0.47 |
| ▸ | CNR1 | P21554 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.46 |
| ▸ | FAAH | O00519 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5114802 | 0.82 | SCN9A (0.46) | SCN9AMGLLABHD6ALOX5APFEN1 | |
| SCHEMBL4996506 | 0.77 | ALDH1A1 (0.63) | POLBL3MBTL1HSD17B10ALDH1A1 | |
| SCHEMBL2709582 | 0.77 | PDE3B (0.50) | SCN9AHIF1AEPAS1CNR2CNR1 | |
| SCHEMBL29921818 | 0.77 | PDE3B (0.50) | SCN9AHIF1AEPAS1CNR2CNR1 | |
| SCHEMBL25026436 | 0.77 | ALOX5AP (0.57) | SCN9AMGLLABHD6ALOX5APFEN1 | |
| SCHEMBL2228234 | 0.76 | KDM4E (0.58) | CYP2C9ALOX15HSD17B10ALDH1A1 | |
| SCHEMBL4506785 | 0.76 | EPHX2 (0.56) | ALOX5APFEN1FKBP1A | |
| SCHEMBL27808417 | 0.76 | CYP2C9 (0.51) | CNR2CYP2C9ALOX15HSD17B10ALDH1A1 | |
| SCHEMBL24720949 | 0.76 | JAK2 (0.50) | HSD17B10ALDH1A1 | |
| SCHEMBL11813579 | 0.75 | POLB (0.50) | SCN9AHIF1AEPAS1CNR2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2222165-A1 | NOVEL COMPOUNDS AS CANNABINOID RECEPTOR LIGANDS AND USES THEREOF | ABBOTT LABORATORIES (US) | 2010-09-01 | — | — | EP | claimed |
| WO-2009067613-A1 | NOVEL COMPOUNDS AS CANNABINOID RECEPTOR LIGANDS AND USES THEREOF | ABBOTT LABORATORIES (US) | 2009-05-28 | — | — | WO | claimed |