Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | CCNE1 | P24864 | 8/20 | 0.50 |
| ▸ | CDK2 | P24941 | 8/20 | 0.50 |
| ▸ | CCNT1 | O60563 | 3/20 | 0.50 |
| ▸ | CDK9 | P50750 | 3/20 | 0.50 |
| ▸ | CCNE2 | O96020 | 3/20 | 0.50 |
| ▸ | CCNT2 | O60583 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | HTT | P42858 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | PTBP1 | P26599 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 4/20 | 0.43 |
| ▸ | GAA | P10253 | 6/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3445850 | 0.92 | POLB (0.52) | POLBCCNE1CDK2CCNT1CDK9 | |
| SCHEMBL3445773 | 0.92 | POLB (0.46) | POLBCCNE1CDK2CCNT1CDK9 | |
| SCHEMBL3444995 | 0.90 | CCNE1 (0.51) | POLBCCNE1CDK2CCNT1CDK9 | |
| SCHEMBL3446781 | 0.89 | CCNE1 (0.51) | POLBCCNE1CDK2CCNT1CDK9 | |
| SCHEMBL15117718 | 0.85 | CDK2 (0.58) | CCNE1CDK2CCNT1CDK9CCNE2 | |
| SCHEMBL3444312 | 0.85 | CDK2 (0.57) | POLBCCNE1CDK2CCNT1CDK9 | |
| SCHEMBL3444311 | 0.85 | CDK2 (0.57) | POLBCCNE1CDK2CCNT1CDK9 | |
| SCHEMBL3444724 | 0.84 | POLB (0.43) | POLBCCNE1CDK2CCNT1CDK9 | |
| SCHEMBL3446189 | 0.83 | POLB (0.46) | POLBCCNE1CDK2CCNT1CDK9 | |
| SCHEMBL15117980 | 0.83 | CDK2 (0.72) | CCNE1CDK2CCNT1CDK9CCNE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7816350-B2 | Substituted [1,2,3] triazolo[4,5-D]pyrimidines as cdk inhibitors | INSTITUTE OF EXPERIMENTAL BOTANY ASCR (CZ) | 2010-10-19 | — | — | US | claimed |