Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | CDK2 | P24941 | 10/20 | 0.42 |
| ▸ | CCNE1 | P24864 | 8/20 | 0.42 |
| ▸ | CDK1 | P06493 | 2/20 | 0.41 |
| ▸ | CDK9 | P50750 | 4/20 | 0.40 |
| ▸ | CCNT1 | O60563 | 3/20 | 0.40 |
| ▸ | CCNE2 | O96020 | 3/20 | 0.40 |
| ▸ | CCNT2 | O60583 | 2/20 | 0.40 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.38 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.38 |
| ▸ | BCDIN3D | Q7Z5W3 | 2/20 | 0.38 |
| ▸ | GBA1 | P04062 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | FLT3 | P36888 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3445850 | 0.92 | POLB (0.52) | POLBCDK2CCNE1CDK1CDK9 | |
| SCHEMBL3445773 | 0.92 | POLB (0.46) | POLBCDK2CCNE1CDK9CCNT1 | |
| SCHEMBL3445047 | 0.90 | CDK2 (0.43) | POLBCDK2CCNE1CDK1CDK9 | |
| SCHEMBL3445085 | 0.89 | CDK2 (0.42) | POLBCDK2CCNE1CDK1CDK9 | |
| SCHEMBL3455221 | 0.87 | CDK2 (0.43) | POLBCDK2CCNE1CDK1CDK9 | |
| SCHEMBL3445930 | 0.85 | CDK1 (0.49) | POLBCDK2CCNE1CDK1CDK9 | |
| SCHEMBL3445928 | 0.85 | CDK1 (0.49) | POLBCDK2CCNE1CDK1CDK9 | |
| SCHEMBL3446232 | 0.85 | POLB (0.44) | POLBCDK2CCNE1CDK1CDK9 | |
| SCHEMBL3445950 | 0.83 | POLB (0.52) | POLBCDK2CCNE1CDK9CCNT1 | |
| SCHEMBL3444814 | 0.83 | CDK2 (0.60) | POLBCDK2CCNE1CDK1CDK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7816350-B2 | Substituted [1,2,3] triazolo[4,5-D]pyrimidines as cdk inhibitors | INSTITUTE OF EXPERIMENTAL BOTANY ASCR (CZ) | 2010-10-19 | — | — | US | claimed |