Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.46 |
| ▸ | GSK3B | P49841 | 3/20 | 0.46 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.46 |
| ▸ | FLT3 | P36888 | 2/20 | 0.46 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.46 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.46 |
| ▸ | PIM1 | P11309 | 1/20 | 0.46 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.45 |
| ▸ | TDO2 | P48775 | 1/20 | 0.45 |
| ▸ | GRM5 | P41594 | 2/20 | 0.44 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.41 |
| ▸ | FYN | P06241 | 1/20 | 0.41 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.41 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.40 |
| ▸ | PRF1 | P14222 | 1/20 | 0.39 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.39 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL34460966 | 0.91 | GSK3B (0.48) | CLK4GSK3BNTRK1FLT3GRM2 | |
| SCHEMBL34460991 | 0.84 | TDO2 (0.48) | CLK4GSK3BNTRK1FLT3GRM2 | |
| SCHEMBL34460999 | 0.84 | CLK4 (0.52) | CLK4GSK3BNTRK1FLT3GRM2 | |
| SCHEMBL34460927 | 0.84 | GRM2 (0.48) | CLK4GSK3BNTRK1FLT3GRM2 | |
| SCHEMBL34460996 | 0.84 | GRM2 (0.50) | CLK4GSK3BNTRK1FLT3GRM2 | |
| SCHEMBL34460995 | 0.83 | GRM2 (0.43) | CLK4GSK3BNTRK1FLT3GRM2 | |
| SCHEMBL34461057 | 0.83 | CLK4 (0.44) | CLK4GSK3BNTRK1FLT3GRM2 | |
| SCHEMBL34460943 | 0.83 | CLK4 (0.47) | CLK4GSK3BNTRK1FLT3GRM2 | |
| SCHEMBL34460938 | 0.83 | GRM2 (0.44) | CLK4GSK3BNTRK1FLT3GRM2 | |
| SCHEMBL34460931 | 0.82 | GRM2 (0.48) | CLK4GSK3BNTRK1FLT3GRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260098030-A1 | NEGATIVE ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTOR 2 | UNIV VANDERBILT (US) | 2026-04-09 | — | — | US | claimed |
| US-20260098030-A1 | NEGATIVE ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTOR 2 | UNIV VANDERBILT (US) | 2026-04-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20260098030-A1 | NEGATIVE ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTOR 2 | GRM2, GRM1, GRIN2C | CLK4 2198/4885GSK3B 3405/4885NTRK1 505/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.