SCHEMBL3446158

SCHEMBL3446158

COc1cc(O)c(CNc2nc(NC(CO)C(C)C)nc3c2nnn3C(C)C)c(O)c1

nearest known ligand 0.48

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
CDK1 P06493 9/20 0.48
CCNB2 O95067 3/20 0.48
CCNB1 P14635 3/20 0.48
CCNB3 Q8WWL7 3/20 0.48
CDK2 P24941 11/20 0.47
CCNE1 P24864 2/20 0.43
CDK5 Q00535 8/20 0.42
CDK5R1 Q15078 8/20 0.42
KDM4E B2RXH2 1/20 0.42
MAPT P10636 1/20 0.42
CLK1 P49759 1/20 0.42
RAB9A P51151 1/20 0.42
CCNA2 P20248 7/20 0.39
CCNA1 P78396 7/20 0.39
DYRK1A Q13627 7/20 0.39
CCNE2 O96020 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3446165 1.00 CDK1 (0.48) CDK1CCNB2CCNB1CCNB3CDK2
SCHEMBL3446260 0.91 CDK1 (0.47) CDK1CCNB2CCNB1CCNB3CDK2
SCHEMBL3446257 0.91 CDK1 (0.47) CDK1CCNB2CCNB1CCNB3CDK2
SCHEMBL3444367 0.89 CDK2 (0.51) CDK1CCNB2CCNB1CCNB3CDK2
SCHEMBL3444363 0.89 CDK2 (0.51) CDK1CCNB2CCNB1CCNB3CDK2
SCHEMBL3445168 0.88 CDK1 (0.49) CDK1CCNB2CCNB1CCNB3CDK2
SCHEMBL3444599 0.88 CDK1 (0.45) CDK1CCNB2CCNB1CCNB3CDK2
SCHEMBL3444605 0.88 CDK1 (0.45) CDK1CCNB2CCNB1CCNB3CDK2
SCHEMBL3445883 0.84 CDK2 (0.42) CDK1CDK2CCNE1CDK5CDK5R1
SCHEMBL3446765 0.84 CDK1 (0.49) CDK1CCNB2CCNB1CCNB3CDK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7816350-B2 Substituted [1,2,3] triazolo[4,5-D]pyrimidines as cdk inhibitors INSTITUTE OF EXPERIMENTAL BOTANY ASCR (CZ) 2010-10-19 US claimed