Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARB | P10826 | 15/20 | 0.71 |
| ▸ | RARG | P13631 | 15/20 | 0.71 |
| ▸ | RARA | P10276 | 13/20 | 0.71 |
| ▸ | RXRA | P19793 | 3/20 | 0.58 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | CA7 | P43166 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5846741 | 0.97 | RARB (0.65) | RARBRARGRARARXRAPDK2 | |
| SCHEMBL5845556 | 0.90 | RARG (0.57) | RARBRARGRARARXRAPDK2 | |
| SCHEMBL5845951 | 0.88 | RARG (0.56) | RARBRARGRARARXRAPDK2 | |
| SCHEMBL5845436 | 0.88 | RARB (0.61) | RARBRARGRARARXRAPDK2 | |
| SCHEMBL5845582 | 0.87 | RARB (0.69) | RARBRARGRARARXRA | |
| SCHEMBL6730351 | 0.85 | RARB (0.53) | RARBRARGRARARXRAPDK2 | |
| SCHEMBL5846311 | 0.85 | RARG (0.56) | RARBRARGRARARXRAPDK2 | |
| SCHEMBL5846056 | 0.84 | RARB (0.59) | RARBRARGRARARXRAPDK2 | |
| SCHEMBL10002006 | 0.84 | RARG (0.71) | RARBRARGRARARXRA | |
| SCHEMBL5846075 | 0.83 | RARB (0.60) | RARBRARGRARARXRAPDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8362082-B2 | Biphenyl compound selective agonists of gamma RAR receptors | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2013-01-29 | — | — | US | disclosed |
| US-8362082-B2 | Biphenyl compound selective agonists of gamma RAR receptors | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2013-01-29 | — | — | US | disclosed |
| US-8362082-B2 | Biphenyl compound selective agonists of gamma RAR receptors | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2013-01-29 | — | — | US | disclosed |
| US-8106235-B2 | Biphenyl compound selective agonists of gamma RAR receptors | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2012-01-31 | — | — | US | disclosed |
| US-8106235-B2 | Biphenyl compound selective agonists of gamma RAR receptors | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2012-01-31 | — | — | US | disclosed |
| US-8106235-B2 | Biphenyl compound selective agonists of gamma RAR receptors | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2012-01-31 | — | — | US | disclosed |
| US-20120016031-A1 | BIPHENYL COMPOUND SELECTIVE AGONISTS OF GAMMA RAR RECEPTORS | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2012-01-19 | — | — | US | disclosed |
| US-20120016031-A1 | BIPHENYL COMPOUND SELECTIVE AGONISTS OF GAMMA RAR RECEPTORS | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2012-01-19 | — | — | US | disclosed |
| US-20120016031-A1 | BIPHENYL COMPOUND SELECTIVE AGONISTS OF GAMMA RAR RECEPTORS | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2012-01-19 | — | — | US | disclosed |
| US-8049034-B2 | Biphenyl compound selective agonists of gamma RAR receptors | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2011-11-01 | — | — | US | disclosed |
| US-20090036536-A1 | Biphenyl compound selective agonists of gamma RAR receptors | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2009-02-05 | — | — | US | disclosed |
| US-20090023811-A1 | Biphenyl compound selective agonists of gamma RAR receptors | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2009-01-22 | — | — | US | disclosed |
| US-20090023811-A1 | Biphenyl compound selective agonists of gamma RAR receptors | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2009-01-22 | — | — | US | disclosed |
| US-20090023811-A1 | Biphenyl compound selective agonists of gamma RAR receptors | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2009-01-22 | — | — | US | disclosed |
| EP-1692093-B1 | BIPHENYL DERIVATIVES USEFUL AS LIGANDS THAT ACTIVATE THE RAR RECEPTORS, PROCESS FOR PREPARING THEM AND USE THEREOF IN HUMAN MEDICINE AND IN COSMETICS | GALDERMA RES & DEV (FR) | 2008-11-19 | — | — | EP | disclosed |
| WO-2007068580-A1 | BIPHENYL DERIVATIVES AS SELECTIVE AGONISTS OF GAMMA RAR RECEPTOR | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2007-06-21 | — | — | WO | disclosed |
| WO-2007068579-A1 | BIPHENYL DERIVATIVES AS SELECTIVE AGONISTS OF GAMMA RAR RECEPTORS | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2007-06-21 | — | — | WO | disclosed |
| US-20070021473-A1 | Novel ligand activators of the RAR receptors and pharmaceutical/cosmetic applications thereof | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2007-01-25 | — | — | US | disclosed |
| EP-1692093-A1 | BIPHENYL DERIVATIVES USEFUL AS LIGANDS THAT ACTIVATE THE RAR RECEPTORS, PROCESS FOR PREPARING THEM AND USE THEREOF IN HUMAN MEDICINE AND IN COSMETICS | Galderma Research & Development, S.N.C. (FR) | 2006-08-23 | — | — | EP | disclosed |
| WO-2005056516-A1 | BIPHENYL DERIVATIVES USEFUL AS LIGANDS THAT ACTIVATE THE RAR RECEPTORS, PROCESS FOR PREPARING THEM AND USE THEREOF IN HUMAN MEDICINE AND IN COSMETICS | GALDERMA RESEARCH & DEVELOPMENT, S.N.C. (FR) | 2005-06-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090023811-A1 | Biphenyl compound selective agonists of gamma RAR receptors | RARG, RARB, RARA | RARB 2/4885RARG 1/4885RARA 3/4885 |
| US-20120016031-A1 | BIPHENYL COMPOUND SELECTIVE AGONISTS OF GAMMA RAR RECEPTORS | RARG, RARB, RARA | RARB 2/4885RARG 1/4885RARA 3/4885 |
| US-20070021473-A1 | Novel ligand activators of the RAR receptors and pharmaceutical/cosmetic applications thereof | RARA, RARB, RARG | RARB 2/4885RARG 3/4885RARA 1/4885 |
| US-20090036536-A1 | Biphenyl compound selective agonists of gamma RAR receptors | RARG, RARB, RARA | RARB 2/4885RARG 1/4885RARA 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.