Sugi Predict

Sugi Predict / Compounds / SCHEMBL3448367

SCHEMBL3448367

SCHEMBL3448367

CN1[C@@H](CC(=O)c2ccccc2)CCC[C@H]1CC(=O)c1ccccc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
▸ KCNH2 Q12809 1/20 0.79
▸ CYP2D6 P10635 4/20 0.77
▸ CYP1A2 P05177 2/20 0.77
▸ TSHR P16473 1/20 0.77
▸ NFKB1 P19838 1/20 0.77
▸ LMNA P02545 1/20 0.77
▸ CHRNB2 P17787 1/20 0.77
▸ HTR2A P28223 1/20 0.77
▸ HRH1 P35367 1/20 0.77
▸ CHRNA7 P36544 1/20 0.77
▸ CHRNA4 P43681 1/20 0.77
▸ SLC18A2 Q05940 1/20 0.77

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL3980827 0.98 KCNH2 (0.77) KCNH2CYP2D6CYP1A2TSHRNFKB1
SCHEMBL5949379 0.93 KCNH2 (0.70) KCNH2CYP2D6CYP1A2TSHRNFKB1
SCHEMBL5949064 0.91 KCNH2 (0.68) KCNH2CYP2D6CYP1A2TSHRNFKB1
SCHEMBL5949448 0.91 KCNH2 (0.68) KCNH2CYP2D6CYP1A2TSHRNFKB1
SCHEMBL5949362 0.91 KCNH2 (0.68) KCNH2CYP2D6CYP1A2TSHRNFKB1
Lobeline SCHEMBL290804 0.88 CYP2D6 (1.00) KCNH2CYP2D6CYP1A2TSHRNFKB1
Lobeline SCHEMBL290803 0.88 CYP2D6 (1.00) KCNH2CYP2D6CYP1A2TSHRNFKB1
Lobeline SCHEMBL13900378 0.88 CYP2D6 (1.00) KCNH2CYP2D6CYP1A2TSHRNFKB1
Lobeline SCHEMBL2905547 0.88 CYP2D6 (1.00) KCNH2CYP2D6CYP1A2TSHRNFKB1
Lobeline SCHEMBL8305826 0.88 CYP2D6 (1.00) KCNH2CYP2D6CYP1A2TSHRNFKB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 114 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9226944-B2 Herbal preparation for sleep apnea relief FRANK STEVEN R (US) 2016-01-05 — — US claimed
US-20100015261-A1 HERBAL PREPARATION FOR SLEEP APNEA RELIEF FRANK STEVEN R 2010-01-21 — — US claimed
US-7511147-B2 Process for manufacturing of chiral lobelin BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) 2009-03-31 — — US claimed
US-20060014791-A1 Process for manufacturing of chiral lobelin BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) 2006-01-19 — — US claimed
US-6087376-A BLOCKING DOPAMINE UPTAKE FOR TREATING BRAIN TRAUMA, EATING DISORDERS, PSYCHOSIS, SLEEP DISORDERS, MYASTHENIA GRAVIS, PARKINSON'S DISEASE, SCHIZOPHRENIA, TOURETTE'S SYNDROME, HUNTINGTON'S DISEASE AND ATTENTION DEFICIT DISORDERS UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (US) 2000-07-11 — — US claimed
US-5830904-A Lobeline compounds as a treatment for psychostimulant abuse and withdrawal, and for eating disorders UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (US) 1998-11-03 — — US claimed
US-20230404915-A1 RAPIDLY DISINTERGRATING COMPOSTIONS AND METHODS (Nicotine) Orcosa Inc. (US) 2023-12-21 — — US disclosed
EP-4243771-A1 RAPIDLY INFUSING COMPOSITIONS AND METHODS Orcosa Inc. (US) 2023-09-20 — — EP disclosed
WO-2022104059-A1 RAPIDLY INFUSING COMPOSITIONS AND METHODS Orcosa Inc. (US) 2022-05-19 — — WO disclosed
CN-106389788-B It is a kind of for enhancing the drug extract, preparation and preparation method of immunologic function of livestock and birds and anti-virus ability 青岛农业大学 2019-09-13 — — CN disclosed
CN-106496099-B The synthetic method of 2- [(2R, 6S) -6- [(2S) -2- hydroxyl -2- phenethyl] -1- methyl piperidine] -1- acetophenone 和鼎（南京）医药技术有限公司 2019-03-15 — — CN disclosed
CN-106496099-B The synthetic method of 2- [(2R, 6S) -6- [(2S) -2- hydroxyl -2- phenethyl] -1- methyl piperidine] -1- acetophenone 和鼎（南京）医药技术有限公司 2019-03-15 — — CN disclosed
CN-108272884-A Treat the pharmaceutical composition and preparation method thereof of hepatitis B 王宏奎 2018-07-13 — — CN disclosed
US-5332784-A Conjugated diene, vinylaromatic copolymer ASAHI KASEI KOGYO KABUSHIKI KAISHA (JP) 1994-07-26 — — US disclosed
US-5115035-A Modified block copolymer of conjugated diene and vinylaromatic and a tackifier resin ASAHI KASEI KOGYO KABUSHIKI KAISHA (JP) 1992-05-19 — — US disclosed
US-4966916-A DI-AND TRIMETHYLAMINOETHYL BENZOATES, PHENYLCARBAMATES AND PHENYLTHIOCARBAMATES UNIVERSITY OF ROCHESTER 1990-10-30 — — US disclosed
US-4966916-A DI-AND TRIMETHYLAMINOETHYL BENZOATES, PHENYLCARBAMATES AND PHENYLTHIOCARBAMATES UNIVERSITY OF ROCHESTER 1990-10-30 — — US disclosed
US-4835162-A 3-QUINUCLIDINYL BENZOATE OR METHYL CARBAMATE UNIVERSITY OF ROCHESTER 1989-05-30 — — US disclosed
US-4835162-A 3-QUINUCLIDINYL BENZOATE OR METHYL CARBAMATE UNIVERSITY OF ROCHESTER 1989-05-30 — — US disclosed
EP-0245505-A1 TERMINAL-MODIFIED BLOCK COPOLYMER AND COMPOSITION CONTAINING SAID COPOLYMER Asahi Kasei Kogyo Kabushiki Kaisha (JP) 1987-11-19 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060014791-A1 Process for manufacturing of chiral lobelin CYP3A7, COASY, CHRNA7 KCNH2 2428/4885CYP2D6 1262/4885CYP1A2 52/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.