SCHEMBL3450180

SCHEMBL3450180

O=C(O)/C=C1\CCc2cc(OCc3ccccc3)ccc21

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOB P27338 11/20 0.57
MAOA P21397 9/20 0.57
HRH3 Q9Y5N1 1/20 0.47
TOP1 P11387 1/20 0.47
NPC1 O15118 3/20 0.46
RAB9A P51151 3/20 0.46
ALDH1A1 P00352 2/20 0.46
HPGD P15428 1/20 0.46
NFKB1 P19838 1/20 0.46
GRM5 P41594 1/20 0.46
NFKB2 Q00653 1/20 0.46
RELA Q04206 1/20 0.46
SMN1; SMN2 Q16637 1/20 0.46
NPSR1 Q6W5P4 1/20 0.46
KDM4E B2RXH2 1/20 0.46
PKM P14618 1/20 0.46
POLB P06746 1/20 0.45
GFER P55789 1/20 0.45
PAX8 Q06710 1/20 0.45
KLF5 Q13887 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3450181 1.00 MAOB (0.57) MAOBMAOAHRH3TOP1NPC1
SCHEMBL3411631 0.90 MAOB (0.57) MAOBMAOAHRH3TOP1NPC1
SCHEMBL3411634 0.90 MAOB (0.57) MAOBMAOAHRH3TOP1NPC1
SCHEMBL3404626 0.88 MAOB (0.53) MAOBMAOAHRH3TOP1NPC1
SCHEMBL3404627 0.88 MAOB (0.53) MAOBMAOAHRH3TOP1NPC1
SCHEMBL3966174 0.86 MAOB (0.51) MAOBMAOAHRH3ALDH1A1L3MBTL1
SCHEMBL3966171 0.86 MAOB (0.51) MAOBMAOAHRH3ALDH1A1L3MBTL1
SCHEMBL3450500 0.83 MAOA (0.54) MAOBMAOANPC1RAB9AHPGD
SCHEMBL3450504 0.83 MAOA (0.54) MAOBMAOANPC1RAB9AHPGD
SCHEMBL3854161 0.82 MAOA (0.53) MAOBMAOAHRH3NPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7820837-B2 ethyl {6-[(3-phenoxybenzyl)oxy]-3,4-dihydronaphthalen-1-yl}acetate; having a GPR40 receptor function modulating action and being useful as an insulin secretagogue or a pharmaceutical agent for the prophylaxis or treatment of diabetes TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2010-10-26 US disclosed
EP-1630152-A1 CONDENSED RING COMPOUND Takeda Pharmaceutical Company Limited (JP) 2006-03-01 EP disclosed