Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 3/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT5B | Q4FZB7 | 2/20 | 0.45 |
| ▸ | KMT5C | Q86Y97 | 2/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.45 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.44 |
| ▸ | CDC7 | O00311 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19174443 | 0.98 | CTSK (0.60) | CTSKALDH1A1KDM4EMALT1L3MBTL1 | |
| SCHEMBL27819587 | 0.96 | CTSK (0.54) | CTSKALDH1A1KDM4EMALT1L3MBTL1 | |
| SCHEMBL17544472 | 0.93 | MALT1 (0.57) | CTSKALDH1A1KDM4EMALT1L3MBTL1 | |
| SCHEMBL3807631 | 0.85 | MALT1 (0.50) | CTSKALDH1A1MALT1KMT2AHRH3 | |
| SCHEMBL12526894 | 0.85 | HRH3 (0.68) | CTSKALDH1A1MALT1KMT2AHRH3 | |
| SCHEMBL31135484 | 0.85 | MERTK (0.54) | CTSKALDH1A1MALT1KMT2AHRH3 | |
| SCHEMBL13213387 | 0.85 | MALT1 (0.50) | CTSKALDH1A1MALT1KMT2AHRH3 | |
| SCHEMBL19462069 | 0.85 | MAPK1 (0.49) | CTSKALDH1A1MALT1KMT2AHRH3 | |
| SCHEMBL26179070 | 0.83 | MALT1 (0.45) | CTSKALDH1A1KDM4EMALT1L3MBTL1 | |
| Hydrochloric Acid SCHEMBL1748490 | 0.83 | HRH3 (0.66) | CTSKALDH1A1MALT1KMT2AHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111423437-B | Preparation method of palbociclib intermediate | 天津法莫西医药科技有限公司 | 2021-02-26 | — | — | CN | claimed |
| CN-111423437-A | Preparation method of palbociclib intermediate | 天津法莫西医药科技有限公司 | 2020-07-17 | — | — | CN | claimed |
| CN-111423437-B | Preparation method of palbociclib intermediate | 天津法莫西医药科技有限公司 | 2021-02-26 | — | — | CN | disclosed |
| CN-111423437-A | Preparation method of palbociclib intermediate | 天津法莫西医药科技有限公司 | 2020-07-17 | — | — | CN | disclosed |
| CN-102203070-A | Alkoxy-and alkylthio-substituted anilinopyrimidines | BAYER CROPSCIENCE AG | 2011-09-28 | — | — | CN | disclosed |
| US-7820704-B2 | Substituted heteroaryl derivatives, compositions, and methods of use | TRANSTECH PHARMA, INC. (US) | 2010-10-26 | — | — | US | disclosed |
| CN-1946703-A | Substituted thiazole and pyrimidine derivatives as melanocortin receptor modulators | TRANSTECH PHARMA INC (US) | 2007-04-11 | — | — | CN | disclosed |
| EP-1753735-A1 | SUBSTITUTED THIAZOLE AND PYRIMIDINE DERIVATIVES AS MELANOCORTIN RECEPTOR MODULATORS | Transtech Pharma, Inc. (US) | 2007-02-21 | — | — | EP | disclosed |
| US-20050261294-A1 | Substituted heteroaryl derivatives, compositions, and methods of use | VTVX HOLDINGS I LLC | 2005-11-24 | — | — | US | disclosed |
| WO-2005103022-A1 | SUBSTITUTED THIAZOLE AND PYRIMIDINE DERIVATIVES AS MELANOCORTIN RECEPTOR MODULATORS | TRANSTECH PHARMA, INC. (US) | 2005-11-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050261294-A1 | Substituted heteroaryl derivatives, compositions, and methods of use | MC5R, MC3R, MC4R | CTSK 2740/4885ALDH1A1 1513/4885KDM4E 2378/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.